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BioMed Research International
Volume 2014 (2014), Article ID 291280, 8 pages
http://dx.doi.org/10.1155/2014/291280
Research Article

A Systematic Analysis of miRNA-mRNA Paired Variations Reveals Widespread miRNA Misregulation in Breast Cancer

1Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
2Department of Bioinformatics, Harbin Medical University, Harbin 150081, China
3Department of Internal Medicine, Cancer Hospital Affiliated to Harbin Medical University, Harbin 150040, China

Received 16 March 2014; Accepted 16 April 2014; Published 18 May 2014

Academic Editor: Zhixi Su

Copyright © 2014 Lei Zhong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate gene expression by binding to target mRNAs and induce translation repression or RNA degradation. There have been many studies indicating that both miRNAs and mRNAs display aberrant expression in breast cancer. Previously, most researches into the molecular mechanism of breast cancer examined miRNA expression patterns and mRNA expression patterns separately. In this study, we systematically analysed miRNA-mRNA paired variations (MMPVs), which are miRNA-mRNA pairs whose pattern of regulation can vary in association with biopathological features, such as the oestrogen receptor (ER), TP53 and human epidermal growth factor receptor 2 (HER2) genes, survival time, and breast cancer subtypes. We demonstrated that the existence of MMPVs is general and widespread but that there is a general unbalance in the distribution of MMPVs among the different biopathological features. Furthermore, based on studying MMPVs that are related to multiple biopathological features, we propose a potential crosstalk mechanism between ER and HER2.