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BioMed Research International
Volume 2014, Article ID 293687, 7 pages
http://dx.doi.org/10.1155/2014/293687
Research Article

The Influence of BMX Gene Polymorphisms on Clinical Symptoms after Mild Traumatic Brain Injury

1Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
2Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
3Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
4Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan
5Department of Emergency Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
6Ministry of Health and Welfare, Taipei 10341, Taiwan
7Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan
8Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 11031, Taiwan

Received 30 December 2013; Accepted 4 March 2014; Published 22 April 2014

Academic Editor: Shuen-Iu Hung

Copyright © 2014 Yu-Jia Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.