Table 1: Selected GO terms of biological processes significantly affected by microgravity. The complete list of GO terms can be found in Supplementary Table S6.

GO:IDTermCount valueFold enrichmentFDR

GO:0045087Innate immune response252,42 × 10−52,5669781930,040412626
GO:0009966Regulation of signal transduction881,67 × 10−41,4715778790,27973741
GO:0048468Cell development621,71 × 10−41,6103388490,285253218
GO:0045595Regulation of cell differentiation542,68 × 10−41,6480,448057857
GO:0006954Inflammatory response413,23 × 10−41,7875132280,539044451
GO:0080134Regulation of response to stress375,43 × 10−41,8066962960,90478009
GO:0010646Regulation of cell communication958,22 × 10−41,3805996471,366092587
GO:0048513Organ development1398,22 × 10−41,2909101161,366713032
GO:0042060Wound healing268,38 × 10−42,0259101651,393334889
GO:0007165Signal transduction1980,0013986031,2112249442,313943814
GO:0001817Regulation of cytokine production270,0014060031,9262337662,326052387
GO:0048514Blood vessel morphogenesis260,0017091871,930090092,820918727
GO:0001817Regulation of cytokine production150,0014060031,9262337662,326052387
GO:0007399Nervous system development880,0020970261,3598124713,450524099
GO:0022603Regulation of anatomical structure morphogenesis280,0024083691,8311111113,953172097
GO:0048870Cell motility330,0028388261,7101886794,64407324
GO:0048522Positive regulation of cellular process1590,0035512591,2215944065,777298149
GO:0002684Positive regulation of immune system process310,0038551111,7114907876,256755641
GO:0050865Regulation of cell activation260,0038808391,8194479836,297247375
GO:0051174Regulation of phosphorus metabolic process510,0039646041,4862599476,428964883
GO:0001944Vasculature development280,0039817831,7679693496,455956993
GO:0043066Negative regulation of apoptosis410,0040408031,569523816,548633436
GO:0010941Regulation of cell death830,0041159091,3410196086,666445839
GO:0009617Response to bacterium220,0049918241,90320218,030143455
GO:0043067Regulation of programmed cell death820,005523741,3287708958,849108723
GO:0008285Negative regulation of cell proliferation400,005760071,547417849,210770389
GO:0010557Positive regulation of macromolecule biosynthetic process620,0065437931,3901496610,4004889
GO:0016477Cell migration300,0067065051,66464646510,64564555
GO:0042127Regulation of cell proliferation710,0098484331,33114903315,2576907
GO:0048523Negative regulation of cellular process1390,0125143641,1987022518,9945349