Review Article

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

Table 1

Markers for distinguishing activated and resting microglia.

NameMarkers References

CD11bBoth resting and activated M/M[24, 75]
CD45Nucleated hematopoietic cell surface[30, 76]
CD68 (ED1)*Active phagocytosis M/M[24, 45, 77]
Iba-1Both resting and activated M/M [78, 79]
F4/80 Both resting and activated M/M[35, 43]
IB4Both resting and activated M/M[15]
Ym-1Activated M/M (M2)[24]
Iba-1+, CD206+Activated M/M (M2)[24]
Iba-1+, CD16/32+Activated M/M (M1)[41]

CD68 and ED1 are virtually the same molecule (CD68 is used more in the human context, while ED1 is the name of that protein in rodents). M/M: microglia and macrophages.