BioMed Research International / 2014 / Article / Tab 1

Review Article

Signalling Molecules in the Urothelium

Table 1

Signalling molecules and receptor expression in urothelial cells.

Signalling moleculeReceptorMethod of detection

ΑChMuscarinic (M1–M5)IHC, IB [48]  
RT-PCR [151]

AChNicotinic (subunits alpha 3, 5, 7, 9, and 10 and beta 3 and 4)RT-PCR [37, 41]

AdenosinePurinergic (P1 or AR-A1, A2a, A2b, and A3)IB [96, 102]

ATPPurinergic (P2X1–7 and P2Y1,2,4)ICC, IB, and PCR [152]  
RT-PCR [78]

A/NAAdrenergic (1A, 1D, and 1–3)IB, IHC [153]  
ISH [154],  
RT-PCR [130]

VIP/PACAPPAC1, VPAC1, and VPAC2ICC [155]  
RT-PCR [156]

EGFEGFRIHC [157]

Substance PTachykinin (NK1)IB, IHC, and RT-PCR [158]

BradykininBradykinin (B2)ICC, RT-PCR [159]

Display of a selection of signalling molecules and their corresponding receptors shown to be expressed in the urothelium, as well as the methods used for receptor detection. ACh: acetylcholine; ATP: adenosine 5′-triphosphate; A: adrenaline; NA: noradrenaline; VIP: vasoactive intestinal peptide; PACAP: pituitary adenylate cyclase activating polypeptide; PAC: pituitary adenylate cyclase; VPAC: vasoactive intestinal peptide receptor; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; RT-PCR: reverse transcriptase polymerase chain reaction; IHC: immunohistochemistry; IB: immunoblotting; ICC: immunocytochemistry; ISH: in situ hybridization.

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