Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 305610, 7 pages
http://dx.doi.org/10.1155/2014/305610
Research Article

Phytochemical Prospection and Modulation of Antibiotic Activity In Vitro by Lippia origanoides H.B.K. in Methicillin Resistant Staphylococcus aureus

1Laboratory of Microbiology and Immunology, Campus Amílcar Ferreira Sobral, Universidade Federal do Piauí, BR 343, Km 3,5 Bairro Meladão, 64800-000 Floriano, PI, Brazil
2Center for Research on Medicinal Plants, Universidade Federal do Piauí, Bairro Ininga, 64049-550 Teresina, PI, Brazil
3Laboratory of Clinical Microbiology, Universidade Federal da Paraiba, Cidade Universitária, 58051-900 João Pessoa, PB, Brazil
4Laboratory of Microbiology, Faculdade de Ensino Superior de Floriano, Bairro Manguinha, 64800-000 Floriano, PI, Brazil
5Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Bairro Pimenta, 63105-100 Crato, CE, Brazil
6Laboratory of Natural Products, Universidade Federal do Piauí, Bairro Ininga, 64049-550 Teresina, PI, Brazil

Received 8 December 2013; Revised 6 January 2014; Accepted 6 January 2014; Published 10 February 2014

Academic Editor: Aramati B. Reddy

Copyright © 2014 Humberto Medeiros Barreto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. ŠLširak, A. Zvizdić, and M. Hukić, “Methicillin-resistant Staphylococcus aureus (MRSA) as a cause of nosocomial wound infections,” Bosnian Journal of Basic Medical Sciences, vol. 10, no. 1, pp. 32–37, 2010. View at Google Scholar · View at Scopus
  2. F. Razera, S. de Stefani, R. R. Bonamigo, G. S. Olm, C. A. G. Dias, and G. A. Narvaez, “CA MRSA in furunculosis: case report of Southern Brazil,” Anais Brasileiros de Dermatologia, vol. 84, no. 5, pp. 515–518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Shittu, U. Nübel, E. Udo, J. Lin, and S. Gaogakwe, “Characterization of meticillin-resistant Staphylococcus aureus isolates from hospitals in KwaZulu-Natal province, Republic of South Africa,” Journal of Medical Microbiology, vol. 58, no. 9, pp. 1219–1226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Otto, “Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus,” Annual Review of Microbiology, vol. 64, pp. 143–162, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Seymour and J. Golding, “Hospital-acquired and community-acquired MRSA: two distinct infections,” Emergency Medicine, vol. 41, no. 10, pp. 36–41, 2009. View at Google Scholar · View at Scopus
  6. M. Otto, “Methicillin-resistant Staphylococcus aureus infection is associated with increased mortality,” Future Microbiology, vol. 7, no. 2, pp. 189–191, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Kumar and M. F. Varela, “Biochemistry of bacterial multidrug efflux pumps,” International Journal of Molecular Sciences, vol. 13, no. 4, pp. 4484–4495, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Kumar and S. Chopra, “New drugs for methicillin-resistant Staphylococcus aureus: an update,” Journal of Antimicrobial Chemotherapy, vol. 68, no. 7, pp. 1465–1470, 2013. View at Publisher · View at Google Scholar
  9. T. D. Tran, T. H. Do, N. C. Tran et al., “Synthesis and anti-Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics,” Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 14, pp. 4555–4560, 2012. View at Publisher · View at Google Scholar
  10. E. F. F. Matias, K. K. A. Santos, T. S. Almeida, J. G. M. Costa, and H. D. M. Coutinho, “Phytochemical prospection and modulation of aminoglycoside antibiotic activity by Croton campestris A,” Chemotherapy, vol. 57, no. 4, pp. 305–309, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J.-M. Bolla, S. Alibert-Franco, J. Handzlik et al., “Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria,” FEBS Letters, vol. 585, no. 11, pp. 1682–1690, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Gibbons, “Phytochemicals for bacterial resistance—strengths, weaknesses and opportunities,” Planta Medica, vol. 74, no. 6, pp. 594–602, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. E. I. T. Damasceno, J. K. R. Silva, E. H. A. Andrade, P. J. C. Sousa, and J. G. S. Maia, “Antioxidant capacity and larvicidal activity of essential oil and extracts from Lippia grandis,” Brazilian Journal of Pharmacognosy, vol. 21, no. 1, pp. 78–85, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. E. Stashenko, J. R. Martínez, C. A. Ruíz et al., “Lippia origanoides chemotype differentiation based on essential oil GC-MS and principal component analysis,” Journal of Separation Science, vol. 33, no. 1, pp. 93–103, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. E. Pascual, K. Slowing, E. Carretero, D. Sánchez Mata, and A. Villar, “Lippia: traditional uses, chemistry and pharmacology: a review,” Journal of Ethnopharmacology, vol. 76, no. 3, pp. 201–214, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Caballero-Gallardo, J. Olivero-Verbel, and E. E. Stashenko, “Repellency and toxicity of essential oils from Cymbopogon martini, Cymbopogon flexuosus and Lippia origanoides cultivated in Colombia against Tribolium castaneum,” Journal of Stored Products Research, vol. 50, pp. 62–65, 2012. View at Publisher · View at Google Scholar
  17. A. R. Borges, J. R. A. Aires, T. M. M. Higino et al., “Trypanocidal and citotoxic activities of essential oils from medicinal plants of Northeast of Brazil,” Experimental Parasitology, vol. 132, no. 2, pp. 123–128, 2012. View at Publisher · View at Google Scholar
  18. D. I. Ospina, V. Álvarez, H. G. Torres, M. S. Sánchez, and C. R. Bonilla, “Evaluación de la actividad inhibitoria de aceites esenciales de Lipppia origanoides H.B.K. sobre el desarollo micelial y la formación de esclerócios de Sclerotium cepivorum Berk,” Acta Agronomica, vol. 60, pp. 306–311, 2011. View at Google Scholar
  19. V. Tangarife-Castaño, J. Correa-Royero, B. Zapata-Lodoño, C. Durán, E. Stanshenko, and A. C. Mesa-Arango, “Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic and medicinal plants,” Infection, vol. 15, pp. 160–167, 2011. View at Google Scholar
  20. G. C. Vicuña, E. E. Stashenko, and J. L. Fuentes, “Chemical composition of the Lippia origanoides essential oils and their antigenotoxicity against bleomycin-induced DNA damage,” Fitoterapia, vol. 81, no. 5, pp. 343–349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. F. J. B. dos Santos, J. A. D. Lopes, A. M. G. L. Cito, E. H. de Oliveira, S. G. de Lima, and F. D. A. M. Reis, “Composition and biological activity of essential oils from Lippia origanoides H.B.K,” Journal of Essential Oil Research, vol. 16, no. 5, pp. 504–506, 2004. View at Google Scholar · View at Scopus
  22. V. A. Isidorov, A. G. Isidorova, L. Sczczepaniak, and U. Czyzewska, “Gas chromatographic-mass spectrometric investigation of the chemical composition of beebread,” Food Chemistry, vol. 115, no. 3, pp. 1056–1063, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. M. Javadpour, M. M. Juban, W.-C. J. Lo et al., “De novo antimicrobial peptides with low mammalian cell toxicity,” Journal of Medicinal Chemistry, vol. 39, no. 16, pp. 3107–3113, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. H. D. M. Coutinho, J. G. M. Costa, V. S. Falcão-Silva, J. P. Siqueira-Júnior, and E. O. Lima, “Potentiation of antibiotic activity by eugenia uniflora and eugenia jambolanum,” Journal of Medicinal Food, vol. 13, no. 4, pp. 1024–1026, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. C. A. Tanaka, C. C. da Silva, B. P. D. Filho, C. V. Nakamura, J. E. de Carvalho, and M. A. Foglio, “Chemical constituents of Luehea divaricata Mart. (Tiliaceae),” Quimica Nova, vol. 28, no. 5, pp. 834–837, 2005. View at Google Scholar · View at Scopus
  26. R. Dall'Agnol, A. Ferraz, A. P. Bernardi et al., “Antimicrobial activity of some Hypericum species,” Phytomedicine, vol. 10, no. 6-7, pp. 511–516, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. D. M. Coutinho, J. G. M. Costa, V. S. Falcão-Silva, J. P. Siqueira-Júnior, and E. O. Lima, “In vitro additive effect of Hyptis martiusii in the resistance to aminoglycosides of methicillin-resistant Staphylococcus aureus,” Pharmaceutical Biology, vol. 48, no. 9, pp. 1002–1006, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. E. F. F. Matias, K. K. A. Santos, T. S. Almeida, J. G. M. Costa, and H. D. M. Coutinho, “Enhancement of antibiotic activity by Cordia verbenacea DC,” Latin American Journal of Pharmacy, vol. 29, no. 6, pp. 1049–1052, 2010. View at Google Scholar · View at Scopus
  29. H. D. M. Coutinho, J. G. M. Costa, E. O. Lima, V. S. Falcão-Silva, and J. P. Siqueira Jr., “Potentiating effect of Mentha arvensis and chlorpromazine in the resistance to aminoglycosides of methicillin—resistant Staphylococcus aureus,” In Vivo, vol. 23, no. 2, pp. 287–290, 2009. View at Google Scholar · View at Scopus
  30. M.-P. Mingeot-Leclercq, Y. Glupczynski, and P. M. Tulkens, “Aminoglycosides: activity and resistance,” Antimicrobial Agents and Chemotherapy, vol. 43, no. 4, pp. 727–737, 1999. View at Google Scholar · View at Scopus
  31. N. Duran, B. Ozer, G. G. Duran, Y. Onlen, and C. Demir, “Antibiotic resistance genes & susceptibility patterns in staphylococci,” Indian Journal of Medical Research, vol. 135, no. 3, pp. 389–396, 2012. View at Google Scholar · View at Scopus
  32. S. S. Costa, M. Viveiros, L. Amaral, and I. Couto, “Multidrug efflux pumps in Staphylococcus aureus: an update,” The Open Microbiology Journal, vol. 7, pp. 59–71, 2013. View at Publisher · View at Google Scholar
  33. J. L. Floyd, K. P. Smith, S. H. Kumar, J. T. Floyd, and M. F. Varela, “LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 12, pp. 5406–5412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. B. D. Schindler, P. Jacinto, and G. W. Kaatz, “Inhibition of drug efflux pumps in Staphylococcus aureus: current status of potentiating existing antibiotics,” Future Microbiology, vol. 8, no. 4, pp. 491–507, 2013. View at Publisher · View at Google Scholar
  35. G. W. Kaatz, V. V. Moudgal, S. M. Seo, and J. E. Kristiansen, “Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus,” Antimicrobial Agents and Chemotherapy, vol. 47, no. 2, pp. 719–726, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. C. C. Liolios, O. Gortzi, S. Lalas, J. Tsaknis, and I. Chinou, “Liposomal incorporation of carvacrol and thymol isolated from the essential oil of Origanum dictamnus L. and in vitro antimicrobial activity,” Food Chemistry, vol. 112, no. 1, pp. 77–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Nostro, A. R. Blanco, M. A. Cannatelli et al., “Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol,” FEMS Microbiology Letters, vol. 230, no. 2, pp. 191–195, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. E. L. Souza, C. E. V. Oliveira, T. L. M. Stamford, M. L. Conceição, and N. J. G. Neto, “Influence of carvacrol and thymol on the physiological attributes, enterotoxin production and surface characteristics of Staphylococcus aureus strains isolated from foods,” Brazilian Journal of Microbiology, vol. 44, no. 1, pp. 29–35, 2013. View at Publisher · View at Google Scholar
  39. R. J. W. Lambert, P. N. Skandamis, P. J. Coote, and G.-J. E. Nychas, “A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol,” Journal of Applied Microbiology, vol. 91, no. 3, pp. 453–462, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Tsuchiya, M. Sato, T. Miyazaki et al., “Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus,” Journal of Ethnopharmacology, vol. 50, no. 1, pp. 27–34, 1996. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Xiao, H. Cao, Y. Wang, J. Zhao, and X. Wei, “Glycosylation of dietary flavonoids decreases the affinities for plasma protein,” Journal of Agricultural and Food Chemistry, vol. 57, no. 15, pp. 6642–6648, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. G. L. de Azevedo Maia, V. dos Santos Falcão-Silva, P. G. V. Aquino et al., “Flavonoids from Praxelis clematidea R.M. King and Robinson modulate bacterial drug resistance,” Molecules, vol. 16, no. 6, pp. 4828–4835, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. V. S. Falcão-Silva, D. A. Silva, M. D. F. V. Souza, and J. P. Siqueira Jr., “Modulation of drug resistance in Staphylococcus aureus by a kaempferol glycoside from Herissantia tiubae (Malvaceae),” Phytotherapy Research, vol. 23, no. 10, pp. 1367–1370, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. A. S. Roccaro, A. R. Blanco, F. Giuliano, D. Rusciano, and V. Enea, “Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells,” Antimicrobial Agents and Chemotherapy, vol. 48, no. 6, pp. 1968–1973, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Duda-Chodak, “The inhibitory effect of polyphenols on human gut micro biota,” Journal of Physiology and Pharmacology, vol. 63, pp. 497–503, 2012. View at Google Scholar
  46. G. Mandalari, R. N. Bennett, G. Bisignano et al., “Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry,” Journal of Applied Microbiology, vol. 103, no. 6, pp. 2056–2064, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. G. Céliz, M. Daz, and M. C. Audisio, “Antibacterial activity of naringin derivatives against pathogenic strains,” Journal of Applied Microbiology, vol. 111, no. 3, pp. 731–738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. E. Durante-Mangoni, A. Grammatikos, R. Utili, and M. E. Falagas, “Do we still need the aminoglycosides?” International Journal of Antimicrobial Agents, vol. 33, no. 3, pp. 201–205, 2009. View at Publisher · View at Google Scholar · View at Scopus