The Antileukemia Activity of Natural Product HQ17(3) Is Possibly Associated with Downregulation of miR-17-92 Cluster
Monitoring of c-Myc activity upon treatment with HQ17(3) and putative reactive hot spot. (a) K562 cells were transfected with a c-Myc reporter with/without treatment with 3 μM HQ17(3). c-Myc activity was monitored 24 h after the treatment. The experiments were repeated five times. Mean ± SD is shown. compared to mock. (b) Sequence homology was found when c-Myc and topo IIα were aligned.