Production and Cytotoxicity of Extracellular Insoluble and Droplets of Soluble Melanin by Streptomyces lusitanus DMZ-3

Table 4

Cytotoxic activity of the insoluble and soluble melanins.

Concentration of melanin; (𝜇g/mL)	Log of concentration of melanin	Survived brine shrimps			Percent mortality			Lc50 (𝜇g/mL) at 24 h
		6 h	12 h	24 h	6 h	12 h	24 h
Insoluble melanin
01.0	0	19	11	06	10	45	70	0.80
02.0	0.301	17	11	07	15	45	65
04.0	0.602	17	10	06	15	50	70
08.0	0.903	17	09	04	15	55	80
16.0	1.204	16	09	04	20	55	80
32.0	1.505	16	09	03	20	55	85
64.0	1.806	16	07	01	20	65	95
Soluble melanin
01.0	0	17	05	04	15	75	80	0.40
02.0	0.301	17	05	04	15	75	80
04.0	0.602	16	05	04	20	75	80
08.0	0.903	16	05	04	20	75	80
16.0	1.204	15	05	03	25	75	85
32.0	1.505	15	04	02	25	80	90
64.0	1.806	15	03	00	25	85	100