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BioMed Research International
Volume 2014, Article ID 307519, 18 pages
Review Article

Recent Advances in Application of Biosensors in Tissue Engineering

1Biomedical Engineering and Department of Mechanical Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut 1107 2020, Lebanon
2Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4Department of Chemical and Biological Engineering, Korea National University of Transportation, 50 Daehak-ro, Chungju 380-702, Republic of Korea
5Tissue Engineering Centre, Faculty of Medicine, National University of Malaysia (Universiti Kebangsaan Malaysia), 56000 Cheras, Kuala Lumpur, Malaysia
6Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS 66045-7609, USA
7Surface Engineering & Tribology Division, CSIR-Central Mechanical Engineering Research Institute, Mahatma Gandhi Avenue, Durgapur, West Bengal 713209, India
8Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon

Received 28 February 2014; Accepted 28 May 2014; Published 6 August 2014

Academic Editor: Min-Hsien Wu

Copyright © 2014 Anwarul Hasan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications in numerous industries including food and beverages, agricultural, environmental, medical diagnostics, and pharmaceutical industries and many more. Even though numerous biosensors have been developed for detection of proteins, peptides, enzymes, and numerous other biomolecules for diverse applications, their applications in tissue engineering have remained limited. In recent years, there has been a growing interest in application of novel biosensors in cell culture and tissue engineering, for example, real-time detection of small molecules such as glucose, lactose, and H2O2 as well as serum proteins of large molecular size, such as albumin and alpha-fetoprotein, and inflammatory cytokines, such as IFN-g and TNF-α. In this review, we provide an overview of the recent advancements in biosensors for tissue engineering applications.