Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 309307, 11 pages
http://dx.doi.org/10.1155/2014/309307
Research Article

Development and Characterization of New Monoclonal Antibodies against Human Recombinant CA XII

1Institute of Biotechnology, Vilnius University, V. A. Graiciuno 8, 20241 Vilnius, Lithuania
2School of Medicine and Institute of Biomedical Technology, University of Tampere and Fimlab Ltd., Medisiinarinkatu 3, 33520 Tampere, Finland

Received 19 August 2013; Accepted 7 April 2014; Published 20 May 2014

Academic Editor: Nathalie M. Mazure

Copyright © 2014 Dovile Dekaminaviciute et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. A. Whittington, A. Waheed, B. Ulmasov et al., “Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 17, pp. 9545–9550, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Thiry, J.-M. Dogné, B. Masereel, and C. T. Supuran, “Targeting tumor-associated carbonic anhydrase IX in cancer therapy,” Trends in Pharmacological Sciences, vol. 27, no. 11, pp. 566–573, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. P.-O. Nyman and S. Lindskog, “Amino acid composition of various forms of bovine and human erythrocyte carbonic anhydrase,” Biochimica et Biophysica Acta, vol. 85, no. 1, pp. 141–151, 1964. View at Google Scholar · View at Scopus
  4. M. Imtaiyaz Hassan, B. Shajee, A. Waheed, F. Ahmad, and W. S. Sly, “Structure, function and applications of carbonic anhydrase isozymes,” Bioorganic & Medicinal Chemistry, vol. 21, no. 6, pp. 1570–1582, 2013. View at Google Scholar
  5. A. Kivela, S. Parkkila, J. Saarnio et al., “Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors,” The American Journal of Pathology, vol. 156, no. 2, pp. 577–584, 2000. View at Google Scholar · View at Scopus
  6. M. I. Ilie, V. Hofman, C. Ortholan et al., “Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis,” International Journal of Cancer, vol. 128, no. 7, pp. 1614–1623, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. Ö. Türeci, U. Sahin, E. Vollmar et al., “Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 13, pp. 7608–7613, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Leppilampi, J. Saarnio, T. J. Karttunen et al., “Carbonic anhydrase isozymes IX and XII in gastric tumors,” World Journal of Gastroenterology, vol. 9, no. 7, pp. 1398–1403, 2003. View at Google Scholar · View at Scopus
  9. P. C. McDonald, J. Y. Winum, C. T. Supuran, and S. Dedhar, “Recent developments in targeting carbonic anhydrase IX for cancer therapeutics,” Oncotarget, vol. 3, no. 1, pp. 84–97, 2012. View at Google Scholar
  10. J. Chiche, K. Ilc, J. Laferrière et al., “Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH,” Cancer Research, vol. 69, no. 1, pp. 358–368, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Akurathi, L. Dubois, N. G. Lieuwes et al., “Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia,” Nuclear Medicine and Biology, vol. 37, no. 5, pp. 557–564, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Vullo, A. Innocenti, I. Nishimori et al., “Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides—a new target for the design of antitumor and antiglaucoma drugs?” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 4, pp. 963–969, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Kobayashi, T. Matsumoto, S. Ryuge et al., “CAXII Is a sero-diagnostic marker for lung cancer,” PLOS ONE, vol. 7, no. 3. View at Publisher · View at Google Scholar
  14. C. Battke, E. Kremmer, J. Mysliwietz et al., “Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII,” Cancer Immunology, Immunotherapy, vol. 60, no. 5, pp. 649–658, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Jogaitė, A. Zubrienė, V. Michailovienė, J. Gylytė, V. Morkūnaitė, and D. Matulis, “Characterization of human carbonic anhydrase XII stability and inhibitor binding,” Bioorganic & Medicinal Chemistry, vol. 21, no. 6, pp. 1431–1436, 2013. View at Google Scholar
  16. V. Dudutienė, A. Zubrienė, A. Smirnov et al., “4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII,” Bioorganic & Medicinal Chemistry, vol. 21, no. 7, pp. 2093–2106, 2013. View at Google Scholar
  17. G. Kohler and C. Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,” Nature, vol. 256, no. 5517, pp. 495–497, 1975. View at Google Scholar · View at Scopus
  18. E. Harlow and D. P. Lane, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, NY, USA, 1st edition, 1988.
  19. A. J. Kivela, S. Parkkila, J. Saarnio et al., “Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa,” World Journal of Gastroenterology, vol. 11, no. 17, pp. 2616–2625, 2005. View at Google Scholar · View at Scopus
  20. J. Haapasalo, M. Hilvo, K. Nordfors et al., “Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas,” Neuro-Oncology, vol. 10, no. 2, pp. 131–138, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Oosterwijk, D. J. Ruiter, and J. Hoedemaeker Ph., “Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney,” International Journal of Cancer, vol. 38, no. 4, pp. 489–494, 1986. View at Google Scholar · View at Scopus
  22. J. Tostain, G. Li, A. Gentil-Perret, and M. Gigante, “Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment,” European Journal of Cancer, vol. 46, no. 18, pp. 3141–3148, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. Uniprot Protein Knowledgebase, http://www.uniprot.org/uniprot/O43570.