Evaluation and Comparison of Multiple Aligners for Next-Generation Sequencing Data Analysis
Graphical representation shows alignment accuracy results using in silico short-read datasets with varying error rates. Based on in silico short-read datasets sampled from chromosome X of H. sapiens with varying error rates (e.g., 0%, 0.2%, 0.5%, 0.8%, and 1.0%, resp.), (a) and (b) show accuracy evaluation by sensitivity and precision, respectively. Aligners with (*) in (b) are used to show alignment accuracy evaluation by precision with consideration of multimapped reads.