BioMed Research International / 2014 / Article / Fig 2

Review Article

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

Figure 2

Organelles, such as mitochondria, peroxisome, and ER, dysfunction causes accumulation of reactive oxygen species (ROS) and ER stress in diabetic kidney. Dietary restriction enhances autophagy-lysosomal degradation system, leading to cell or tissue homeostasis. Nutrient-sensing signal and organella maintenance in diabetic nephropathy (DN).

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