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BioMed Research International
Volume 2014 (2014), Article ID 316082, 8 pages
http://dx.doi.org/10.1155/2014/316082
Research Article

Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

1Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil
2Department of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, Brazil

Received 27 February 2014; Revised 14 April 2014; Accepted 15 April 2014; Published 7 May 2014

Academic Editor: Terry K. Smith

Copyright © 2014 Ivanildo Mangueira da Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.