Research Article

Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

Table 1

Antimicrobial activity of compounds tested against different microorganisms (diameter of inhibition halo in mm).

Microorganisms
Synthetized compounds
(300 µg/disc)
Gram-positive bacteria Gram-negative bacteriaAlcohol acid resistant bacteriaYeast
n Subs.S. aureus  
DAUFPE  
01
M. luteus  
DAUFPE  
06
E. faecalis  
DAUFPE  
138
B. subtilis  
DAUFPE  
16
P. aeruginosa  
DAUFPE  
39
E. coli  
DAUFPE  
224
S. marcescens  
DAUFPE  
398
M. smegmatis  
DAUFPE  
71
C. albicans  
DAUFPE  
1007

1000000000
2a3-OCH3  
4-OH
19.3 ± 0.4727.8 ± 0.1611.2 ± 0.6215.0 ± 0.1615.0 ± 0.160019.3 ± 0.7716.2 ± 0.82
2b2,4-Cl11.7 ± 0.5632.0 ± 0.8118.8 ± 0.8530.7 ± 0.4700019.2 ± 0.410
2c3,4-Cl19.4 ± 0.0834.0 ± 0.808.4 ± 0.1725.4 ± 0.0500012.1 ± 0.090
2d4-OH013.8 ± 0.5611.0 ± 0.82000000
2e3-OCH3012.7 ± 0.560000000
2f3-CH318.3 ± 0.47018.8 ± 0.1617.8 ± 0.6200000
2g3-NO221.8 ± 0.16022.8 ± 0.7023.7 ± 0.1600000
2h4-NO223.8 ± 0.16021.9 ± 0.1718.6 ± 0.150000
2i3-Cl20.8 ± 0.2724.8 ± 0.1621.8 ± 0.1627.7 ± 0.1600000

Kan
(30 μg/disc)
23.0 ± 0.8228.3 ± 0.09014.0 ± 0.8220.0 ± 0.1215.1 ± 0.1915.0 ± 0.1240.0 ± 0.12
Cef
(30 μg/disc)
35.3 ± 0.0954.0 ± 0.1224.1 ± 0.1945.0 ± 0.12024.3 ± 0.0900
Ket
(300 μg/disc)
24.1 ± 0.19

Standard compounds: Cef: cephalexin; Ket: ketoconazole; Kan: kanamycin.
—: not tested; : medium; : standard deviation.