Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

Table 2

Inhibition and bactericidal concentrations of compounds (2a–i), with respect to different microorganisms (μg/mL).

Synthetized compounds	Microorganisms
	S. aureus; DAUFPE 01		M. luteus; DAUFPE 06		B. subtilis; DAUFPE 16		M. smegmatis; DAUFPE 71		E. faecalis; DAUFPE 138		C. albicans; DAUFPE 1007
	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC
2a	16	32	4	8	4	8	16	32	64	>128	8	32
2b	8	16	2	4	2	4	2	4	16	32	—	—
2c	8	16	2	4	2	4	2	4	16	32	—	—
2d	—	—	4	8	—	—	—	—	—	—	—	—
2e	—	—	4	8	—	—	—	—	—	—	—	—
2f	16	32	16	32	4	8	—	—	—	—	—	—
2g	8	16	8	16	16	32	—	—	—	—	—
2h	8	16	8	16	—	—	—	—	—	—	—	—
2i	8	16	16	32	4	8	—	—	—	—	—	—
Cefalexin	8	16	<2	2	<2	<2	>128	>128	>128	>128	—	—
Ketoconazole	—	—	—	—	—	—	—	—	—	—	<2	2

MIC: minimum inhibitory concentration;
MBC: minimum bactericidal concentration;
—: not tested.