BioMed Research International / 2014 / Article / Tab 1

Review Article

Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

Table 1

Characteristics of the different reviewed studies on mp-MRI for the diagnosis of local recurrence after RP.

AuthorsMRI scanStudy designCasesMean PSAMean lesion size Reference standardT2WIDCEMRSIDWICombined techniques

Silverman and Kerbs [3]ERC 1.5-T Prospective411.4 ng/dL16 mmTRUS biopsySe 100%
Spe 100%
PPV 100%
NPV 100%

Sella et al. [4]PAC + ERC 1.5-T Retrospective482.18 ng/dL14 mmTRUS biopsy, PSA reduction after RT, increase lesion size at MRISe 95%
Spe 100%

Cirillo et al. [5] PAC + ERC 1.5-T Retrospective721.51 ng/dL17 mmTRUS biopsy, Cho-PET findings, PSA reduction after RT Se 61.4%
Sp 82.1%
PPV 84.4%
NPV 57.5%
Acc 69.4%
Se 84.1%
Spe 89.3%
PPV 92.5%
NPV 78.1%
Acc 86.1%

Casciani et al. [6] PAC + ERC 1.5-T Retrospective461.9 ng/dL15 mmTRUS biopsy,
PSA reduction after RT
Se 48%
Sp 52%
PPV 54%
NPV 46%
Acc 48%
Se 88%
Spe 100%
PPV 100%
NPV 88%
Acc 94%

Sciarra et al. [7]PAC + ERC 1.5-T Prospective701.2 ng/dL (group A)
0.8 ng/dL (group B)
13 mm (group A)
6 mm (group B)
TRUS biopsy (group A)
PSA reduction after RT (group B)
Se 71–79%
Spe 94–100%
PPV 96–100%
NPV 67–79%
0.923–0.931
Se 71–84%
Spe 83–88%
PPV 91–93%
NPV 56–74%
0.81–0.942
MRSI + DCE:
Se 86-87%
Spe 94–100%
PPV 96–100%
NPV 75–79%
0.964–0.94

Panebianco et al. [8]PAC + ERC 3.0-T Prospective841.1 ng/dL (group A)
1.9 ng/dL (group B)
6 mm (group A)
13 mm (group B)
TRUS biopsy (group B)
PSA reduction after RT (group A)
MRSI + DCE:
Se 92–94%
Spe 75–100%
PPV 96–100%
NPV 57–60%
Acc 89–94%
0.833–0.971

Wu et al. [9]Meta-analysisSe 72%
Spe 74%
Se 85%
Spe 95%
MRSI + DCE:
Se 92%
Spe 95%

Panebianco et al. [10]PAC + ERC 3.0-T Prospective2621.3 ng/dL (group A)
2.0 ng/dL (group B)
5 mm (group A)
12 mm (group B)
TRUS biopsy (group A)
PSA reduction after RT (group B)
T2WI + DCE:
Se 98–100%
Spe 94–97%
PPV 96-97%
NPV 95-96%
Acc 91%
0.875–0.917
T2WI + DWI
Se 97-98%
Spe 95-96%
PPV 93–96%
NPV 91–95%
Acc 89–92%
0.783–0.823

Roy et al. [11]PAC + ERC 3.0-T Retrospective280.98 ng/dLTRUS biopsySe 56%Se 94%Se 50%Se 65%T2WI + DCE: Se 97%
T2WI + DWI + DCE:
Se 94%
T2WI + DWI + DCE + MRS:
Se 74%
T2WI + DWI: Se 65%
T2WI + MRS: 53%

PAC: phased-array coil; ERC: endorectal coil; Se: sensitivity; Spe: specificity; PPV: positive predictive value; NPV: negative predictive value; Acc: accuracy; : area under the receiver operating characteristic curve.

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