Research Article

A New Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for Haplotyping of VKORC1 Gene to Predict Warfarin Sensitivity

Table 1

The four SNPs required to infer the VKORC1 haplotypes. The replacement of VKORC1 381 with VKORC1 3673, 6484, 6853, or 7566 was possible because these five SNPs were tightly linked.

VKORC1 SNPHGSVHaplotype
WT variantMut variant

381296C>TC = see 5808T = see 9041
58085723T>GT = H1G = H2
90418956G>AG = H9A = see 861
861776C>AC = H7A = H8