Peroxynitrite and Peroxiredoxin in the Pathogenesis of Experimental Amebic Liver Abscess
Figure 3
Amebic peroxiredoxin in ALA. During the development of ALA, activated phagocytes produce increased levels of superoxide () and NO, thus generating the ONOO− anion, which in turn causes oxidative damage to hepatocytes. ONOO− can decompose into nitrogen dioxide (•NO2) and the highly oxidizing hydroxyl radical (•OH). The ONOO− anion can be intercepted by direct reaction with carbon dioxide, decomposing it into nontoxic products. The Prx enzymes of parasites (e.g., E. histolytica) and other bacteria are involved in protection of these organisms by the reduction of host-produced hydrogen peroxides and ONOO−.
