Wnt Pathway Activation in Long Term Remnant Rat Model

Table 2

Summary of differentially regulated genes.

Gene symbol	12 weeks	18 weeks	12 weeks versus 18 weeks
Fibrosis related genes
BMP4	↓n.s.	↓	↓
BMP7	↑n.s.	↔	↔
Col1a1	↑n.s.	↑n.s.	↑n.s.
FSP1	↑n.s.	↑	↑
Vim	↑n.s.	↑	↔
Wnt pathway ligands
Wnt1	↑n.s.	↑n.s.	↑n.s.
Wnt3a	↑n.s.	↑n.s.	↑n.s.
Wnt5a	↓n.s.	↓n.s.	↔
Wnt7b	↑n.s.	↑n.s.	↔
Wnt10a	↓n.s.	↓n.s.	↔
Receptors
FZD1	↓n.s.	↓	↓
FZD3	↓n.s.	↓n.s.	↔
FZD6	↔	↓n.s.	↔
FZD8	↓n.s.	↓	↔
LRP5	↓n.s.	↓n.s.	↔
Intracellular signal transducers
𝛽-Cat	↑n.s.	↑	↑
GSK-3𝛽	↓n.s.	↓n.s.	↑n.s.
Target
Axin2	↑n.s.	↔	↔
LEF1	↑n.s.	↑	↔
WISP1	↔	↔	↑n.s.

↑: statistically significant upregulation.
↓: statistically significant downregulation.
↑n.s.: no statistically significant upregulation.
↓n.s.: no statistically significant downregulation.