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BioMed Research International
Volume 2014, Article ID 325725, 11 pages
http://dx.doi.org/10.1155/2014/325725
Review Article

Cardioprotection: A Review of Current Practice in Global Ischemia and Future Translational Perspective

1Department of Cardiac Surgery, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
2Division of Cardiovascular Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
3Department of Dermatology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

Received 19 June 2014; Revised 31 July 2014; Accepted 11 August 2014; Published 8 September 2014

Academic Editor: M.-Saadeh Suleiman

Copyright © 2014 Andreas Habertheuer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Chambers and H. B. Fallouh, “Cardioplegia and cardiac surgery: pharmacological arrest and cardioprotection during global ischemia and reperfusion,” Pharmacology & Therapeutics, vol. 127, no. 1, pp. 41–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. R. K. Ghanta, P. S. Shekar, S. McGurk, D. M. Rosborough, and S. F. Aranki, “Long-term survival and quality of life justify cardiac surgery in the very elderly patient,” The Annals of Thoracic Surgery, vol. 92, no. 3, pp. 851–857, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Nicolini, A. Agostinelli, A. Vezzani et al., “The evolution of cardiovascular surgery in elderly patient: a review of current options and outcomes,” BioMed Research International, vol. 2014, Article ID 736298, 10 pages, 2014. View at Publisher · View at Google Scholar
  4. A. Hassan, A. Newman, D. T. Ko et al., “Increasing rates of angioplasty versus bypass surgery in Canada, 1994–2005,” American Heart Journal, vol. 160, no. 5, pp. 958–965, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. Ingwall, “Energy metabolism in heart failure and remodelling,” Cardiovascular Research, vol. 81, no. 3, pp. 412–419, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Massberg and K. Messmer, “The nature of ischemia/reperfusion injury,” Transplantation Proceedings, vol. 30, no. 8, pp. 4217–4223, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Fey, D. Follette, J. Livesay et al., “Effects of membrane stabilization on the safety of hypothermic arrest after aortic cross-clamping,” Circulation, vol. 56, no. 3, pp. 143–147, 1977. View at Publisher · View at Google Scholar · View at Scopus
  8. S. M. Goldstein, R. L. Nelson, D. H. McConnell, and G. D. Buckberg, “Effects of conventional hypothermic ischemic arrest and pharmacological arrest on myocardial supply/demand balance during aortic cross clamping,” The Annals of Thoracic Surgery, vol. 23, no. 6, pp. 520–528, 1977. View at Publisher · View at Google Scholar · View at Scopus
  9. L. W. Traverso, B. T. Ferrari, G. D. Buckberg, and R. K. Tompkins, “Elevated postoperative renal clearance of amylase without pancreatitis after cardiopulmonary bypass,” The American Journal of Surgery, vol. 133, no. 3, pp. 298–303, 1977. View at Publisher · View at Google Scholar · View at Scopus
  10. H. B. Barner, “Blood cardioplegia: a review and comparison with crystalloid cardioplegia,” The Annals of Thoracic Surgery, vol. 52, no. 6, pp. 1354–1367, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Øvrum, G. Tangen, S. Tølløfsrud, R. Øystese, M. A. L. Ringdal, and R. Istad, “Cold blood cardioplegia versus cold crystalloid cardioplegia: a prospective randomized study of 1440 patients undergoing coronary artery bypass grafting,” The Journal of Thoracic and Cardiovascular Surgery, vol. 128, no. 6, pp. 860–865, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Øvrum, G. Tangen, S. Tølløfsrud, R. Øystese, M.-A. L. Ringdal, and R. Istad, “Cold blood versus cold crystalloid cardioplegia: a prospective randomised study of 345 aortic valve patients,” European Journal of Cardio-thoracic Surgery, vol. 38, no. 6, pp. 745–749, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Guru, J. Omura, A. A. Alghamdi, R. Weisel, and S. E. Fremes, “Is blood superior to crystalloid cardioplegia? A meta-analysis of randomized clinical trials,” Circulation, vol. 114, no. 1, pp. I331–I338, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. W. A. Anderson, L. D. Berrizbeitia, D. A. Ilkowski et al., “Normothermic retrograde cardioplegia is effective in patients with left ventricular hypertrophy: a prospective and randomized study,” The Journal of Cardiovascular Surgery, vol. 36, no. 1, pp. 17–24, 1995. View at Google Scholar · View at Scopus
  15. F. Dagenais, L. C. Pelletier, and M. Carrier, “Antegrade/retrograde cardioplegia for valve replacement: a prospective study,” The Annals of Thoracic Surgery, vol. 68, no. 5, pp. 1681–1685, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Menasche, F. Tronc, A. Nguyen et al., “Retrograde warm blood cardioplegia preserves hypertrophied myocardium: a clinical study,” Annals of Thoracic Surgery, vol. 57, no. 6, pp. 1429–1435, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. R. N. Gates, H. Laks, D. C. Drinkwater et al., “Gross and microvascular distribution of retrograde cardioplegia in explanted human hearts,” The Annals of Thoracic Surgery, vol. 56, no. 3, pp. 410–417, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Vähäsilta, A. Saraste, V. Kytö et al., “Cardiomyocyte apoptosis after antegrade and retrograde cardioplegia,” Annals of Thoracic Surgery, vol. 80, no. 6, pp. 2229–2234, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Vähäsilta, M. Malmberg, A. Saraste et al., “Cardiomyocyte apoptosis after antegrade and retrograde cardioplegia during aortic valve surgery,” The Annals of Thoracic Surgery, vol. 92, no. 4, pp. 1351–1357, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. A. A. Lotto, R. Ascione, M. Caputo et al., “Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery,” The Annals of Thoracic Surgery, vol. 76, no. 4, pp. 1227–1233, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Radmehr, A. Soleimani, H. Tatari, and M. Salehi, “Does combined antegrade-retrograde cardioplegia have any superiority over antegrade cardioplegia?” Heart, Lung & Circulation, vol. 17, no. 6, pp. 475–477, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Fan, A.-M. Zhang, Y.-B. Xiao, Y.-G. Weng, and R. Hetzer, “Warm versus cold cardioplegia for heart surgery: a meta-analysis,” European Journal of Cardio-thoracic Surgery, vol. 37, no. 4, pp. 912–919, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. H. R. Mallidi, J. Sever, M. Tamariz et al., “The short-term and long-term effects of warm or tepid cardioplegia,” The Journal of Thoracic and Cardiovascular Surgery, vol. 125, no. 3, pp. 711–720, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Ascione, S. M. Suleiman, and G. D. Angelini, “Retrograde hot-shot cardioplegia in patients with left ventricular hypertrophy undergoing aortic valve replacement,” Annals of Thoracic Surgery, vol. 85, no. 2, pp. 454–458, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Caputo, W. C. Dihmis, A. J. Bryan, M.-S. Suleiman, and G. D. Angelini, “Warm blood hyperkalaemic reperfusion (“hot shot”) prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery,” European Journal of Cardio-thoracic Surgery, vol. 13, no. 5, pp. 559–564, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Karthik, A. D. Grayson, A. Y. Oo, and B. M. Fabri, “A survey of current myocardial protection practices during coronary artery bypass grafting,” Annals of the Royal College of Surgeons of England, vol. 86, no. 6, pp. 413–415, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. R. B. Jennings, H. M. Sommers, G. A. Smyth, H. A. Flack, and H. Linn, “Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog,” Archives of Pathology, vol. 70, pp. 68–78, 1960. View at Google Scholar
  28. C. E. Murry, R. B. Jennings, and K. A. Reimer, “Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium,” Circulation, vol. 74, pp. 1124–1136, 1986. View at Google Scholar
  29. A. T. Turer and J. A. Hill, “Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy,” The American Journal of Cardiology, vol. 106, no. 3, pp. 360–368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Motoyama, F. Chen, A. Ohsumi et al., “Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model,” The Journal of Heart and Lung Transplantation, vol. 32, no. 5, pp. 505–510, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Westaby, R. Kharbanda, and A. P. Banning, “Cardiogenic shock in ACS. Part 1: prediction, presentation and medical therapy,” Nature Reviews Cardiology, vol. 9, no. 3, pp. 158–171, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Kaszaki, A. Wolfárd, L. Szalay, and M. Boros, “Pathophysiology of ischemia-reperfusion injury,” Transplantation Proceedings, vol. 38, no. 3, pp. 826–828, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. N. G. Frangogiannis, C. W. Smith, and M. L. Entman, “The inflammatory response in myocardial infarction,” Cardiovascular Research, vol. 53, no. 1, pp. 31–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Galasso, S. Schiekofer, C. D'Anna et al., “No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives,” Angiology, vol. 65, no. 3, pp. 180–189, 2014. View at Publisher · View at Google Scholar
  35. O. Goertz, H. Lauer, L. von der Lohe et al., “Peptide XIB13 reduces capillary leak in a rodent burn model,” Microvascular Research, vol. 93, pp. 98–104, 2014. View at Publisher · View at Google Scholar
  36. P. Petzelbauer, P. A. Zacharowski, Y. Miyazaki et al., “The fibrin-derived peptide Bβ15-42 protects the myocardium against ischemia-reperfusion injury,” Nature Medicine, vol. 11, no. 3, pp. 298–304, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Tani and J. R. Neely, “Role of intracellular na+ in ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of h+-na+ and na+-ca2+ exchange,” Circulation Research, vol. 65, no. 4, pp. 1045–1056, 1989. View at Publisher · View at Google Scholar · View at Scopus
  38. L. R. Bush, J. L. Romson, J. L. Ash, and B. R. Lucchesi, “Effects of diltiazem on extent of ultimate myocardial injury resulting from temporary coronary artery occlusion in dogs,” Journal of Cardiovascular Pharmacology, vol. 4, no. 2, pp. 285–296, 1982. View at Publisher · View at Google Scholar · View at Scopus
  39. E. F. du Toit and L. H. Opie, “Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion,” Circulation Research, vol. 70, no. 5, pp. 960–967, 1992. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Krause and M. L. Hess, “Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia,” Circulation Research, vol. 55, no. 2, pp. 176–184, 1984. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Kaplan, M. Hendrikx, M. Mattheussen, K. Mubagwa, and W. Flameng, “Effect of ischemia and reperfusion on sarcoplasmic reticulum calcium uptake,” Circulation Research, vol. 71, no. 5, pp. 1123–1130, 1992. View at Publisher · View at Google Scholar · View at Scopus
  42. H. K. Eltzschig and T. Eckle, “Ischemia and reperfusion—from mechanism to translation,” Nature Medicine, vol. 17, no. 11, pp. 1391–1401, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Gröger, W. Pasteiner, G. Ignatyev et al., “Peptide Bβ15-42 preserves endothelial barrier function in shock,” PLoS ONE, vol. 4, no. 4, Article ID e5391, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. E. Dejana and D. Vestweber, “The role of VE-cadherin in vascular morphogenesis and permeability control,” Progress in Molecular Biology and Translational Science, vol. 116, pp. 119–144, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Y. Chen and G. Nuñez, “Sterile inflammation: sensing and reacting to damage,” Nature Reviews Immunology, vol. 10, no. 12, pp. 826–837, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. S. S. Iyer, W. P. Pulskens, J. J. Sadler et al., “Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 48, pp. 20388–20393, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. B. McDonald, K. Pittman, G. B. Menezes et al., “Intravascular danger signals guide neutrophils to sites of sterile inflammation,” Science, vol. 330, pp. 362–366, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. I. Sörensen, S. Rong, N. Susnik et al., “Bβ15–42 attenuates the effect of ischemia—reperfusion injury in renal transplantation,” Journal of the American Society of Nephrology, vol. 22, no. 10, pp. 1887–1896, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. D. Wiedemann, S. Schneeberger, P. Friedl et al., “The fibrin-derived peptide Bβ15-42 significantly attenuates ischemia-reperfusion injury in a cardiac transplant model,” Transplantation, vol. 89, no. 7, pp. 824–829, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. S. L. Harley, J. Sturge, and J. T. Powell, “Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 3, pp. 652–658, 2000. View at Publisher · View at Google Scholar · View at Scopus
  51. C. M. L. Beckers, V. W. M. van Hinsbergh, and G. P. van Nieuw Amerongen, “Driving Rho GTPase activity in endothelial cells regulates barrier integrity,” Thrombosis and Haemostasis, vol. 103, no. 1, pp. 40–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. K. Zacharowski, P. A. Zacharowski, P. Friedl et al., “The effects of the fibrin-derived peptide Bβ15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion,” Shock, vol. 27, no. 6, pp. 631–637, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. U. Reisinger, S. Schwaiger, I. Zeller et al., “Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts,” Cardiovascular Research, vol. 82, no. 3, pp. 542–549, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Atar, P. Petzelbauer, J. Schwitter et al., “Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute st-segment elevation myocardial infarction: results of the F.I.R.E. (efficacy of FX06 in the prevention of myocardial reperfusion injury) trial,” Journal of the American College of Cardiology, vol. 53, no. 8, pp. 720–729, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. F. Brunner and L. H. Opie, “Role of endothelin-a receptors in ischemic contracture and reperfusion injury,” Circulation, vol. 97, no. 4, pp. 391–398, 1998. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Orrenius, B. Zhivotovsky, and P. Nicotera, “Regulation of cell death: the calcium-apoptosis link,” Nature Reviews Molecular Cell Biology, vol. 4, no. 7, pp. 552–565, 2003. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Fancelli, A. Abate, R. Amici et al., “Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo,” Journal of Medicinal Chemistry, vol. 57, no. 12, pp. 5333–5347, 2014. View at Publisher · View at Google Scholar
  58. C. Piot, P. Croisille, P. Staat et al., “Effect of cyclosporine on reperfusion injury in acute myocardial infarction,” The New England Journal of Medicine, vol. 359, no. 5, pp. 473–481, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. K. A. Powers, K. Szászi, R. G. Khadaroo et al., “Oxidative stress generated by hemorrhagic shock recruits toll-like receptor 4 to the plasma membrane in macrophages,” The Journal of Experimental Medicine, vol. 203, no. 8, pp. 1951–1961, 2006. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Fenhammar, M. Rundgren, J. Forestier, S. Kalman, S. Eriksson, and R. Frithiof, “Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep,” Anesthesiology, vol. 114, no. 5, pp. 1130–1137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. T. Eckle, D. Kohler, R. Lehmann, K. C. E. Kasmi, and H. K. Eltzschig, “Hypoxia-inducible factor-1 is central to cardioprotection a new paradigm for ischemic preconditioning,” Circulation, vol. 118, no. 2, pp. 166–175, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. H. K. Eltzschig and P. Carmeliet, “Hypoxia and inflammation,” The New England Journal of Medicine, vol. 364, no. 7, pp. 656–665, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. P. Hill, D. Shukla, M. G. B. Tran et al., “Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury,” Journal of the American Society of Nephrology, vol. 19, no. 1, pp. 39–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. W. M. Bernhardt, M. S. Wiesener, P. Scigalla et al., “Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD,” Journal of the American Society of Nephrology, vol. 21, no. 12, pp. 2151–2156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. G. Heusch, K. Boengler, and R. Schulz, “Cardioprotection: nitric oxide, protein kinases, and mitochondria,” Circulation, vol. 118, no. 19, pp. 1915–1919, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. J. P. Roesner, P. Petzelbauer, A. Koch et al., “A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs,” Resuscitation, vol. 80, no. 2, pp. 264–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. T. W. Rice, A. P. Wheeler, G. R. Bernard et al., “A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis,” Critical Care Medicine, vol. 38, no. 8, pp. 1685–1694, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. H. Petrowsky, L. McCormack, M. Trujillo, M. Selzner, W. Jochum, and P. A. Clavien, “A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection,” Annals of Surgery, vol. 244, pp. 921–930, 2006. View at Google Scholar
  69. P. Staat, G. Rioufol, C. Piot et al., “Postconditioning the human heart,” Circulation, vol. 112, no. 14, pp. 2143–2148, 2005. View at Publisher · View at Google Scholar · View at Scopus
  70. H. E. Bøtker, R. Kharbanda, M. R. Schmidt et al., “Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial,” The Lancet, vol. 375, no. 9716, pp. 727–734, 2010. View at Publisher · View at Google Scholar · View at Scopus
  71. S. M. Ryu, H. J. Kim, K. R. Cho, and W.-M. Jo, “Myocardial protective effect of tezosentan, an endothelin receptor antagonist, for ischemia-reperfusion injury in experimental heart failure models,” Journal of Korean Medical Science, vol. 24, no. 5, pp. 782–788, 2009. View at Publisher · View at Google Scholar · View at Scopus