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BioMed Research International
Volume 2014, Article ID 327950, 11 pages
Review Article

Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

1Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea
2Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, India
3Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India
4Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida 203201, India

Received 28 February 2014; Accepted 9 April 2014; Published 15 July 2014

Academic Editor: Surendra Nimesh

Copyright © 2014 Ashish Ranjan Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. “Next generation delivery systems” may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.