Research Article

An Intelligent Clinical Decision Support System for Patient-Specific Predictions to Improve Cervical Intraepithelial Neoplasia Detection

Table 2

Variables characterising patients’ biological status.

Variable nameDescription Value range

Pap testThe result of the cytological examination expressed according to Bethesda system1 : WNL, 2 : ASCUS, 3 : LSIL, 4 : HSIL, 5 : SCC or ADENO-Ca

HPV DNA Arrays: HPV-6, HPV-11, HPV-16, HPV-18, HPV-26, HPV-31, HPV-33, HPV-35, HPV-39, HPV-40, HPV-42, HPV-43, HPV-44, HPV-45, HPV-51, HPV-52, HPV-53, HPV-54, HPV-56, HPV-58, HPV-59, HPV-61, HPV-62, HPV-66, HPV-68, HPV-70, HPV-71, HPV-72, HPV-73, HPV-81, HPV-82, HPV-83, HPV-84, HPV-85, HPV-89The existence of individual subtypes according to the HPV DNA examination0 if the specific subtype is not found, 1 if the specific subtype is found

HR-HPV DNAThe existence of high-risk subtypes found by the HPV DNA test0 if none of the high-risk types was found, 1 if at least one of the high-risk types is found

LR-HPV DNAThe existence of low-risk subtypes found by the HPV DNA test0 if none of the low-risk types is found, 1 if at least one of the low-risk types is found

Arrays numberThe number of HPV subtypes found by the HPV DNA testExpressed as number

N16The result of the NASBA mRNA test for HPV subtype 160 if negative, 1 if positive

N18The result of the NASBA mRNA test for HPV subtype 180 if negative, 1 if positive

N31The result of the NASBA mRNA test for HPV subtype 310 if negative, 1 if positive

N33The result of the NASBA mRNA test for HPV subtype 330 if negative, 1 if positive

N45The result of the NASBA mRNA test for HPV subtype 450 if negative, 1 if positive

FLOWThe result of the identification of E6/E7 mRNA expression of high-risk HPV using flow cytometry technique0 if negative (positive expression <1.5%), 1 if positive (positive expression >1.5%)

p16The result of the p16 immunocytochemical examination 0 if negative, 1 if positive

WNL: within normal limits, ASCUS: atypical squamous cells of unknown significance, LSIL: low-grade intraepithelial lesion, HSIL: high-grade squamous intraepithelial lesion, SCC: squamous cell carcinoma, ADENO-Ca: adenocarcinoma.