An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles

Figure 2

Various isomiR profiles. These miRNAs are the most abundantly up- (green) or downregulated (purple) miRNAs among those examined here. Stably expressed miRNAs are also shown (black). The ordinate axis indicates the relative amount of expression in a specific miRNA locus, and the horizontal axis indicates various types of isomiRs. Blue lines indicate isomiRs from HepG2 cells, and the red line indicates isomiRs from L02 cells. Some miRNAs with 3′ additional nucleotides are also highlighted in the horizontal axis. Stably expressed miRNAs show similar patterns of expression, and deregulated miRNAs show various patterns of expression in those cells. The figure only lists isomiRs (>50 for deregulated miRNAs, >100 for stably expressed miRNAs) for which normalized data was available.