BioMed Research International / 2014 / Article / Tab 2 / Research Article
An Integrated Analysis of miRNA, lncRNA, and mRNA Expression Profiles Table 2 Pathway enrichment analysis of experimentally validated mRNA targets of dominant deregulated miRNAs.
Pathway Number Target genes Cell cycle 18 ATM; CCNA2 CCND1; CCND2 CCNE1 ; CDC25A ; CDK6 ; CDKN1A; CDKN1B; CDKN2A ; E2F1; E2F2 E2F3; EP300; RB1 ; RBL2 TP53; WEE1 Chronic myeloid leukemia 15 ACVR1C ; AKT1; CCND1; CDK6 ; CDKN1A; CDKN1B; CDKN2A ; E2F1; E2F2 E2F3; MYC; NFKB1 ; NRAS RB1 ; TP53 Prostate cancer 15 AKT1; BCL2; CCND1; CCNE1 ; CDKN1A; CDKN1B; E2F1; E2F2 E2F3; EP300; IGF1R; NFKB1 ; NRAS RB1 ; TP53 Pancreatic cancer 14 ACVR1C ; AKT1; CCND1; CDC42 CDK6 ; CDKN2A ; E2F1; E2F2 E2F3; NFKB1 ; RAC1 ; RB1 ; TP53; VEGFA Bladder cancer 13 CCND1; CDKN1A; CDKN2A ; E2F1; E2F2 E2F3; FGFR3; MYC; NRAS RB1 ; THBS1; TP53; VEGFA Melanoma 13 AKT1; CCND1; CDK6 ; CDKN1A; CDKN2A ; E2F1; E2F2 E2F3; IGF1R; MET NRAS RB1 ; TP53 Melanoma 13 AKT1; CCND1; CDK6 ; CDKN1A; CDKN2A ; E2F1; E2F2 E2F3; IGF1R; MET NRAS RB1 ; TP53 Small-cell lung cancer 13 AKT1; BCL2; CCND1; CCNE1 ; CDK6 ; CDKN1B; E2F1; E2F2 E2F3; MYC; NFKB1 ; RB1 ; TP53 Focal adhesion 13 AKT1; BCL2; CCND1; CCND2 CDC42 PAK3 ; IGF1R; MET RAC1 ; RHOA ; ROCK1; THBS1; VEGFA Glioma 12 AKT1; CCND1; CDK6 ; CDKN1A; CDKN2A ; E2F1; E2F2 E2F3; IGF1R; NRAS RB1 ; TP53 Nonsmall cell lung cancer 10 AKT1; CCND1; CDK6 ; CDKN2A ; E2F1; E2F2 E2F3; NRAS RB1 ; TP53 Renal cell carcinoma 10 AKT1; CDC42 PAK3 ; EP300; ETS1 ; HIF1A MET NRAS RAC1 ; VEGFA Axon guidance 10 CDC42 PAK3 ; CXCL12; CXCR4 ; MET NFAT5; NRAS RAC1 ; RHOA ; ROCK1 p53 signaling pathway 9 ATM; CCND1; CCND2 CCNE1 ; CDK6 ; CDKN1A; CDKN2A ; THBS1; TP53 Colorectal cancer 9 ACVR1C ; AKT1; BCL2; CCND1; IGF1R; MET MYC; RAC1 ; TP53 Wnt signaling pathway 9 CCND1; CCND2 EP300; MYC; NFAT5; RAC1 ; RHOA ; ROCK1; TP53 MAPK signaling pathway 9 ACVR1C ; AKT1; CDC42 FGFR3; MYC; NFKB1 ; NRAS RAC1 ; TP53 Adherens junction 8 ACVR1C ; CDC42 EP300; IGF1R; MET RAC1 ; RHOA ; WASF3
These target mRNAs are found to be regulated by at least 2 abnormal miRNAs each. Bold type indicates upregulation. Underlining indicates downregulation. Other fonts indicate stable expression or undetectable levels.
