EZH2 Silencing with RNA Interference Induces G2/M Arrest in Human Lung Cancer Cells In Vitro
Effect of EZH2-siRNA on p53 and p21 protein expression. p53 expression (a) and p21 expression (b) were strongly increased in both A549 and HTB-56 cells after transfection with EZH2-siRNA. (c) Relative expression of p53 mRNA was detected in the presence of GSK 126 or EZH2-siRNA. Each experiment was performed in triplicate.