BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage

<table>GFP+ HNPCs three weeks after transplantation with BDNF in PA gel (Group 2). Immunohistochemical staining was performed with DAPI ((b), (f)) for cell nuclei, GFP ((c), (g)) for transplanted cells, and TUJ1 ((d), (h)) to verify differentiation. Transplanted HNPCs were identified along the auditory nerve “e” and had also migrated to the brain stem “i.” Double-labeled yellow cells (GFP and TUJ1) and neurites (arrowheads) indicate neuronal differentiation ((a), (c), (d), (e), (g), (h), and (i)). CO: cochlea; AN: auditory nerve; BS: brain stem; CN: cochlear nucleus. Scale bar (a) 200 <i>μ</i>m, (b–i) 100 <i>μ</i>m.</table>

BioMed Research International

fig3

Figure 3

Figure 3: BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage 

Figure 3 | BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage 