BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage

Table 1

Animal groups. Group 1 (; survival time 3 weeks) had HNPCs injected to the AN with PA gel applied on the injection site. Group 2 (; survival time 3 weeks) had HNPCs injected to the AN with PA gel including BDNF applied on the injection site. Group 3 (; survival time 6 weeks) had HNPCs injected to the AN with PA gel with BDNF applied on the injection site. Group 4 was the control group (; 3-week survival time) and had medium only without cells injected to the nerve.

Group	Number of animals	-BuTx	HNPC injections	BDNF	PA gel	Survival time
1	3	+	+		+	3 weeks
2	4	+	+	+	+	3 weeks
3	3	+	+	+	+	6 weeks
4	3	+				3 weeks

-BuTx, -bungarotoxin; HNPC, human neural precursor cells; BDNF, brain derived neurotrophic factor; PA, peptide amphiphile.