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BioMed Research International
Volume 2014 (2014), Article ID 357062, 9 pages
http://dx.doi.org/10.1155/2014/357062
Research Article

The Association of Toll-Like Receptor 4 Polymorphism with Hepatitis C Virus Infection in Saudi Arabian Patients

1Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh 11211, Saudi Arabia
2Department of Microbiology and Immunology, Alfaisal University School of Medicine, Riyadh, Saudi Arabia
3Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia
4Molecular BioMedicine Program, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
5Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
6Division of Gastroenterology, Department of Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia
7Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
8Department of Gastroenterology & Hepatology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
9Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Received 1 June 2014; Accepted 9 July 2014; Published 10 August 2014

Academic Editor: Masayuki Kurosaki

Copyright © 2014 Ahmed A. Al-Qahtani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatitis C virus (HCV) is a single stranded RNA virus. It affects millions of people worldwide and is considered as a leading cause of liver diseases including cirrhosis and hepatocellular carcinoma. A recent study reported that TLR4 gene polymorphisms are good prognostic predictors and are associated with protection from liver fibrosis among Caucasians. This study aims to investigate the implication of genetic polymorphisms of TLR4 gene on the HCV infection in Saudi Arabian patients. Two SNPs in the TLR4 gene, rs4986790 (A/G) and rs4986791 (C/T), were genotyped in 450 HCV patients and 600 uninfected controls. The association analysis confirmed that both SNPs showed a significant difference in their distribution between HCV-infected patients and uninfected control subjects (; , 95% –0.581) and (; , 95% –0.443), respectively. More importantly, haplotype analysis revealed that four haplotypes, AC, GT, GC, and AT (rs4986790, rs4986791), were significantly associated with HCV infection when compared with control subjects. One haplotype AC was more prominently found when chronic HCV-infected patients were compared with cirrhosis/HCC patients (frequency = 94.7% and ). Both TLR4 SNPs under investigation were found to be significantly implicated with HCV-infection among Saudi Arabian population.