Contrast Media Viscosity versus Osmolality in Kidney Injury: Lessons from Animal Studies
Figure 5
Renal tissue expression (mRNA levels as analysed by real-time PCR) of kidney injury molecule 1 (KIM-1) and of neutrophil gelatinase associated lipocalin (NGAL) as quantified 24 hours after injection and that of plasminogen activator inhibitor-1 (PAI-1) as quantified 2 hours after injection of either saline, marketed iopromide 300 mg I/mL solution, marketed iodixanol 320 mg I/mL solution, or iodixanol 320 mg I/mL solution with mannitol added to elevate the solution’s osmolality. CM were administered intravenously at a dose 4 g I/kg of body mass. Data are mean ± SEM. * versus saline. Data taken from [35, 40, 58].
