Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Figure 4

Mean relaxations to adenosine (5×10⁻⁵ M) of precontracted (K⁺; 50 mM) isolated urinary bladder strip preparations from control (saline-treated; white) rats and rats with CYP-induced cystitis (black), pretreated with saline (𝑛=10 and 12), 4-DAMP (𝑛=8 and 10), or L-NAME (𝑛=8 in each group). (a) expresses data as absolute values (mN) and (b) as mN/mg. The vertical bars represent the SEM. ^∗∗ denotes 𝑃<0.01 and ^∗∗∗𝑃<0.001.

(a)

(b)