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BioMed Research International
Volume 2014 (2014), Article ID 360936, 4 pages
http://dx.doi.org/10.1155/2014/360936
Clinical Study

The Comparison of the Effects of Sevoflurane Inhalation Anesthesia and Intravenous Propofol Anesthesia on Oxidative Stress in One Lung Ventilation

1Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
2Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey

Received 30 October 2013; Accepted 16 December 2013; Published 5 January 2014

Academic Editor: Ahmet Eroglu

Copyright © 2014 Engin Erturk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA). Material and Methods. Forty-four patients undergoing thoracic surgery with OLV were randomized in two groups (sevoflurane Group S, propofol Group P). Anesthesia was inducted with thiopental and was maintained with 1–2.5% of sevoflurane within the 40/60% of O2/N2O mixture in Group S. In Group P anesthesia was inducted with propofol and was maintained with infusion of propofol and remifentanil. Hemodynamic records and blood samples were obtained before anesthesia induction ( ), 1 min before two lung ventilation ( ), 30 min after two lung ventilation ( ), and postoperative sixth hours ( ). Results. Heart rate at and in Group P was significantly lower than that in Group S. While there were no significant differences in terms of pH and pCO2, pO2 at and in Group S was significantly lower than that in Group P. IMA levels at in Group S were significantly lower than those in Group P. Conclusion. Sevoflurane may offer protection against IRI after OLV in thoracic surgery.