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BioMed Research International
Volume 2014 (2014), Article ID 367103, 9 pages
http://dx.doi.org/10.1155/2014/367103
Research Article

Molecular Profiling and Clinical Outcome of High-Grade Serous Ovarian Cancer Presenting with Low- versus High-Volume Ascites

1Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada M5G 2M9
2Department of Obstetrics and Gynaecology, Trillium Health Partners, 2200 Eglinton Avenue West, Mississauga, ON, Canada L5M 2N1
3Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada M5G 2M9
4Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON, Canada M5T 2M9
5Princess Margaret Genomics Centre, University Health Network, Toronto, ON, Canada M5G 1L7
6Department of Laboratory Medicine and Pathology, Trillium Health Partners, Mississauga, ON, Canada L5M 2N1
7Hospital for Sick Children and Department of Immunology, University of Toronto, Toronto, ON, Canada M5G 1X8
8Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Princess Margaret Cancer Centre, Toronto, ON, Canada M5G 2M9
9Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada M5T 3L9

Received 10 March 2014; Accepted 5 May 2014; Published 25 May 2014

Academic Editor: X. Li

Copyright © 2014 Tomer Feigenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Three supplemental tables are available online. The first of these provides a complete listing of the genes found differentially expressed between HGSOC tumors associated with low-volume ascites and tumors associated with high-volume ascites. The second table presents results of an independent gene set enrichment analysis (GSEA) of the gene expression data, which further supports the interpretation that genes up-regulated in tumors associated with low-volume ascites are involved in immune response. The third Table presents the results of a gene ontology (GO) analysis of genes upregulated in tumors associated with high-volume ascites as compared to tumors associated with low-volume ascites

  1. Supplementary Materials