The Ratio of Estimated Average Glucose to Fasting Plasma Glucose Level Is Superior to Glycated Albumin, Hemoglobin A1c, Fructosamine, and GA/A1c Ratio for Assessing β-Cell Function in Childhood Diabetes

Table 3

Multivariate regression analysis of the eGA/fPG ratio, the GA/A1c ratio, glycated albumin, HbA1c, and fructosamine as a respective dependent variable in patients with T2DM.

Variables	eAG/fPG ratio		GA/A1c ratio		Glycated albumin		HbA1c		Fructosamine
	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2	Model 1	Model 2
HOMA-β	0.517; (<0.001)	0.472; (<0.001)	−0.448; (<0.001)	−0.410; (<0.001)	−0.477; (<0.001)	−0.385; (<0.001)	−0.436; (<0.001)	−0.402; (<0.001)	−0.462; (<0.001)	−0.391; (<0.001)
Age (years)		0.066; (0.814)		0.141; (0.580)		0.063; (0.803)		−0.035; (0.889)		0.074; (0.766)
BMI (kg/m^2)		0.164; (0.495)		−0.660; (<0.001)		−0.465; (<0.001)		−0.133; (0.537)		−0.538; (<0.001)
Duration of diabetes (years)		−0.191; (0.476)		−0.514; (<0.001)		−0.697; (<0.001)		−0.680; (<0.001)		−0.558; (<0.001)
Serum creatinine (mg/dL)		0.145; (0.501)		−0.123; (0.598)		0.108; (0.638)		0.315; (0.186)		0.169; (0.551)
C-peptide (ng/mL)		0.358; (0.041)		−0.106; (0.594)		−0.128; (0.531)		−0.119; (0.566)		−0.065; (0.791)

Correlations between the glycated indices and the various independent variables are expressed as standard β (P value). Model 1: unadjusted; model 2: adjusted for age, BMI, duration of diabetes, serum creatinine, and fasting C-peptide levels.