Polymorphisms at Amino Acid Residues 141 and 154 Influence Conformational Variation in Ovine PrP

Table 1

Sequence conservation scores for amino acid residues in ovine PrP predicted by the Crescendo algorithm. Ovine PrP amino acid residues with conservation scores >1 are listed. The conservation score quantifies the degree of sequence conservation at an alignment position compared to the average sequence conservation. A score of >1 means the sequence conservation is more conserved than that expected based upon its structure.

Conservation; score	Amino acid residue	Structural position
2.28	Met157	Helix-1
2.13	Gln163	β-strand-2
2.08	Met 132	β-strand-1
1.80	Thr194	C-terminus of helix-2
1.73	Thr195	C-terminus of helix-2
1.70	Thr191	C-terminus of helix-2
1.70	Thr219	Helix-3
1.67	Asn176	Helix-2
1.47	His143	β-strand-1-helix-1 loop
1.40	Gln220	Helix-3
1.38	His190	C-terminus of helix-2
1.38	His114	N-terminal domain
1.37	Gln215	Helix-3
1.35	Gln175	Helix-2
1.35	Thr204	Helix-3
1.21	Asn156	Helix-1
1.01	Ala136	β-strand-1