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BioMed Research International
Volume 2014, Article ID 372979, 6 pages
http://dx.doi.org/10.1155/2014/372979
Research Article

Lymphangiogenesis and Its Correlation with the VEGF Expression and the Sentinel Lymph Node in Cutaneous Melanomas

1Department of Pathology, Faculty Hospital, Ostrava, Czech Republic
2Institute of Pathology, School of Medicine, University of Ostrava, Ostrava, Czech Republic
3Center of Nanotechnology, VSB-Technical University, Ostrava, Czech Republic

Received 1 April 2014; Revised 18 May 2014; Accepted 18 May 2014; Published 25 June 2014

Academic Editor: Weibo Cai

Copyright © 2014 Petr Buzrla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Folkman, “Tumor angiogenesis: therapeutic implications,” The New England Journal of Medicine, vol. 285, no. 21, pp. 1182–1186, 1971. View at Google Scholar · View at Scopus
  2. N. Ferrara, H. P. Gerber, and J. LeCouter, “The biology of VEGF and its receptors,” Nature Medicine, vol. 9, no. 6, pp. 669–676, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Shibuya and L. Claesson-Welsh, “Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis,” Experimental Cell Research, vol. 312, no. 5, pp. 549–560, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. G. H. Mahabeleshwar and T. V. Byzova, “Angiogenesis in melanoma,” Seminars in Oncology, vol. 34, no. 6, pp. 555–565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Hirakawa, S. Kodama, R. Kunstfeld, K. Kajiya, L. F. Brown, and M. Detmar, “VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis,” Journal of Experimental Medicine, vol. 201, no. 7, pp. 1089–1099, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. N. E. Tobler and M. Detmar, “Tumor and lymph node lymphangiogenesis—impact on cancer metastasis,” Journal of Leukocyte Biology, vol. 80, no. 4, pp. 691–696, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Salven, P. Heikkilä, and H. Joensuu, “Enhanced expression of vascular endothelial growth factor in metastatic melanoma,” British Journal of Cancer, vol. 76, no. 7, pp. 930–934, 1997. View at Google Scholar · View at Scopus
  8. E. Gallego, L. Vicioso, M. Álvarez et al., “Stromal expression of vascular endothelial growth factor C is relevant to predict sentinel lymph node status in melanomas,” Virchows Archiv, vol. 458, no. 5, pp. 621–630, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Depasquale and W. D. Thompson, “Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF,” Histopathology, vol. 52, no. 4, pp. 500–509, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Simonetti, G. Lucarini, D. Brancorsini et al., “Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions,” Cancer, vol. 95, no. 9, pp. 1963–1970, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Boone, W. Blokx, D. de Bacquer, J. Lambert, D. Ruiter, and L. Brochez, “The role of VEGF-C staining in predicting regional metastasis in melanoma,” Virchows Archiv, vol. 453, no. 3, pp. 257–265, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. S. Dadras, B. Lange-Asschenfeldt, P. Velasco et al., “Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes,” Modern Pathology, vol. 18, no. 9, pp. 1232–1242, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Liu, J. Ma, X. Wang et al., “Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma,” Anatomical Record, vol. 291, no. 10, pp. 1227–1235, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Sahni, A. Robson, G. Orchard, R. Szydlo, A. V. Evans, and R. Russell-Jones, “The use of LYVE-1 antibody for detecting lymphatic involvement in patients with malignant melanoma or known sentinel node status,” Journal of Clinical Pathology, vol. 58, no. 7, pp. 715–721, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Massi, S. Puig, A. Franchi et al., “Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study,” Journal of Clinical Pathology, vol. 59, no. 2, pp. 166–173, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Kashani-Sabet, R. W. Sagebiel, C. M. M. Ferreira, M. Nosrati, and J. R. Miller III, “Tumor vascularity in the prognostic assessment of primary cutaneous melanoma,” Journal of Clinical Oncology, vol. 20, no. 7, pp. 1826–1831, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Depasquale and W. D. Thompson, “Microvessel density for melanoma prognosis,” Histopathology, vol. 47, no. 2, pp. 186–194, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Massi, M. C. de Nisi, A. Franchi et al., “Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis,” Modern Pathology, vol. 22, no. 1, pp. 21–30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Pàez-Ribes, E. Allen, J. Hudock et al., “Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis,” Cancer Cell, vol. 15, no. 3, pp. 220–231, 2009. View at Publisher · View at Google Scholar · View at Scopus