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BioMed Research International
Volume 2014 (2014), Article ID 374828, 7 pages
Research Article

Surface-Based Regional Homogeneity in First-Episode, Drug-Naïve Major Depression: A Resting-State fMRI Study

1Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing 100101, China
2Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, China
3University of Chinese Academy of Sciences, Beijing 100049, China

Received 5 November 2013; Revised 15 January 2014; Accepted 19 January 2014; Published 25 February 2014

Academic Editor: Qiyong Gong

Copyright © 2014 Hui-Jie Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Previous volume-based regional homogeneity (ReHo) studies neglected the intersubject variability in cortical folding patterns. Recently, surface-based ReHo was developed to reduce the intersubject variability and to increase statistical power. The present study used this novel surface-based ReHo approach to explore the brain functional activity differences between first-episode, drug-naïve MDD patients and healthy controls. Methods. Thirty-three first-episode, drug-naïve MDD patients and 32 healthy controls participated in structural and resting-state fMRI scans. MDD patients were rated with a 17-item Hamilton Rating Scale for Depression prior to the scan. Results. In comparison with the healthy controls, MDD patients showed reduced surface-based ReHo in the left insula. There was no increase in surface-based ReHo in MDD patients. The surface-based ReHo value in the left insula was not significantly correlated with the clinical information or the depressive scores in the MDD group. Conclusions. The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information. The surface-based ReHo may be a useful index to explore the pathophysiological mechanism of MDD.