Role of miRNA Let-7 and Its Major Targets in Prostate Cancer

Figure 1

Schematic overview of the miRNA maturation and the way of function in eukaryotic cells. The endogenously expressed primary miRNA (pri-miRNA) is processed in the nucleus of a cell by the enzyme Drosha. The emerging precursor miRNA (pre-miRNA) product is exported into the cytoplasm by Exportin-5 and maturated by Dicer. Finally the guide strand is incorporated into the RNA-induced silencing complex (RISC), which blocks the translation of the target mRNA.