Figure 5: Development of tumour volumes following LVV transduction. Volume changes (mean ± SD) of subcutaneous A549 tumours treated with wild-type control vector (wt IN), active endonuclease containing vector (IN-I-PpoI, I-PpoI in short), or thymidine kinase transgene-containing vector (wt IN+TK) are shown. Group sizes were LVV INwt, ; LVV IN-I-PpoI, ; and LVV INwt TK, . Differences between groups were analyzed by two-way ANOVA and Tukey’s multiple comparisons test. ; to ; to .