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BioMed Research International
Volume 2014, Article ID 379748, 7 pages
http://dx.doi.org/10.1155/2014/379748
Research Article

Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

1Department of Pharmacology & Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8
2Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada M5S 3M2

Received 20 February 2014; Accepted 18 June 2014; Published 1 July 2014

Academic Editor: Thomas Minor

Copyright © 2014 Abdullah Al Maruf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [11 citations]

The following is the list of published articles that have cited the current article.

  • Abdullah Al Maruf, HoYin Lip, Horace Wong, and Peter J. O’Brien, “Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes,” Chemico-Biological Interactions, 2014. View at Publisher · View at Google Scholar
  • Abdullah Al Maruf, and Peter O’Brien, “ Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System ,” Oxidative Medicine and Cellular Longevity, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Nesreen E.M. Mohammed, Basim A.S. Messiha, and Ali A. Abo-Saif, “Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats,” Saudi Pharmaceutical Journal, 2015. View at Publisher · View at Google Scholar
  • Marco Pelin, Sara De Iudicibus, Laura Fusco, Eleonora Taboga, Giulia Pellizzari, Cristina Lagatolla, Stefano Martelossi, Alessandro Ventura, Giuliana Decorti, and Gabriele Stocco, “Role of oxidative stress mediated by glutathione-S-transferase in thiopurines toxic effects,” Chemical Research in Toxicology, pp. 150430114556000, 2015. View at Publisher · View at Google Scholar
  • Mark M. T. J. Broekman, Hennie M. J. Roelofs, Dennis R. Wong, Mariska Kerstholt, Alex Leijten, Frank Hoentjen, Wilbert H. M. Peters, Geert J. A. Wanten, and Dirk J. de Jong, “Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro,” Cell Biology and Toxicology, vol. 31, no. 3, pp. 161–171, 2015. View at Publisher · View at Google Scholar
  • Hui Liu, Liang Ding, Fangbin Zhang, Yu Zhang, Xiang Gao, Pinjin Hu, Huichang Bi, and Min Huang, “The impact of glutathione S–transferase genotype and phenotype on the adverse effects to azathioprine in patients with inflammatory bowel diseases,” Journal of Pharmacological Sciences, 2015. View at Publisher · View at Google Scholar
  • Claudia R. Gordijo, Azhar Z. Abbasi, Mohammad Ali Amini, Ho Yin Lip, Azusa Maeda, Ping Cai, Peter J. O'Brien, Ralph S. DaCosta, Andrew M. Rauth, and Xiao Yu Wu, “ Design of Hybrid MnO 2 -Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment ,” Advanced Functional Materials, 2015. View at Publisher · View at Google Scholar
  • Gabriele Stocco, Gaetana Lanzi, Fengming Yue, Silvia Giliani, Katsunori Sasaki, Alberto Tommasini, Marco Pelin, Stefano Martelossi, Alessandro Ventura, and Giuliana Decorti, “Patients' Induced Pluripotent Stem Cells to Model Drug Induced Adverse Events: A Role in Predicting Thiopurine Induced Pancreatitis?,” Current Drug Metabolism, vol. 17, no. 1, pp. 91–98, 2016. View at Publisher · View at Google Scholar
  • Marco Pelin, Margherita Londero, Riccardo Spizzo, Alessandro Ventura, Giuliana Decorti, Sara De Iudicibus, Sveva Dei Rossi, Stefano Martelossi, and Gabriele Stocco, “Thiopurine biotransformation and pharmacological effects: Contribution of oxidative stress,” Current Drug Metabolism, vol. 17, no. 6, pp. 542–549, 2016. View at Publisher · View at Google Scholar
  • Andrew G.M. Morgan, Dinesh Babu, Karim Michail, and Arno G. Siraki, “An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity,” Toxicology Letters, 2017. View at Publisher · View at Google Scholar
  • Abdullah Al Maruf, Peter J. O’Brien, Parvaneh Naserzadeh, Rozhina Fathian, Ahmad Salimi, and Jalal Pourahmad, “Methotrexate induced mitochondrial injury and cytochrome c release in rat liver hepatocytes,” Drug and Chemical Toxicology, pp. 1–11, 2017. View at Publisher · View at Google Scholar