TY - JOUR A2 - He, Yong AU - Wang, Xiaoxia AU - Feng, Zhengzhi AU - Zhou, Daiquan AU - Lei, Xu AU - Liao, Tongquan AU - Zhang, Li AU - Ji, Bing AU - Li, Jing PY - 2014 DA - 2014/04/03 TI - Dissociable Self Effects for Emotion Regulation: A Study of Chinese Major Depressive Outpatients SP - 390865 VL - 2014 AB - Reappraisal is an adaptive emotion regulation strategy while the role of self-perspective in reappraisal process of depressed patients is largely unknown in terms of goals (valence/arousal) and tactics (detachment/immersion). In this study, 12 depressed individuals and 15 controls were scanned with MRI during which they either attend naturally to emotional stimuli, or adopt detachment/immersion strategy. Behaviorally, no group differences in self-reported emotion regulation effectiveness were found. In addition, we observed that (1) patients were less able to downregulate amygdala activation with recruitment of more dorsal lateral prefrontal cortex (dlPFC) when adopting detachment strategy regardless of valence, and this preserved ability to regulate emotion was inversely associated with severity of symptoms; (2) patients had deficits in upregulating amygdala activation when adopting immersion strategy, with less inferior frontal gyrus (IFG) activation and strengthening coupling of dlPFC and ventral medial prefrontal cortex (vmPFC) with amygdala; (3) comparison between groups yielded that patients showed stronger vmPFC activation under either self-detached or self-immersed condition. In conclusion, impaired modulatory effects of amygdala in depressed patients are compensated with strengthening cognitive control resources, with dissociable effects for different self-perspectives in reappraisal. These results may help clarify the role of self-perspective underlying reappraisal in major depression. SN - 2314-6133 UR - https://doi.org/10.1155/2014/390865 DO - 10.1155/2014/390865 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -