Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

Table 2

Changes in hemodynamic indices, body weight, and function capacity.

Item	At baseline	4 weeks later	8 weeks later	12 weeks later
Systolic blood pressure (mmHg)
Testosterone group	119.92±16.99	121.60±12.99	122.84±9.49	125.92±15.67
Placebo group	126.12±18.87	122.24±19.17	121.24±18.38	120.74±28.45
𝑃 value	0.232	0.891	0.700	0.434
Diastolic blood pressure (mmHg)
Testosterone group	81.17±18.77	75.80±9.70	76.44±7.58	79.00±9.99
Placebo group	79.04±8.94	73.76±8.95	72.68±19.27	76.13±8.26
𝑃 value	0.613	0.444	0.369	0.286
Heart rate (bpm*)
Testosterone group	71.21±8.83	70.48±9.49	69.92±6.84	70.88±8.78
Placebo group	69.52±7.56	71.28±7.12	68.56±8.60	71.52±7.94
𝑃 value		0.738	0.539	0.792
Body weight (Kg)
Testosterone group	76.66±10.42	75.88±10.35	75.84±10.26	75.46±9.96
Placebo group	73.12±12.67	74.00±12.47	74.28±11.92	74.52±11.92
𝑃 value	0.286	0.565	0.622	0.768
6MWD^† (m)
Testosterone group	407.44±100.23	466.58±93.33	476.67±96.59	491.65±112.88
Placebo group	338.25±125.60	394.17±98.37	421.52±99.14	416.09±121.57
𝑃 value	0.038	0.012	0.044	0.034
Muscle strength (kgf)
Testosterone group	37.64±9.64	39.60±8.19	41.60±9.57	42.12±9.06
Placebo group	35.17±10.54	36.68±6.87	38.88±7.73	38.65±8.17
𝑃 value	0.411	0.178	0.278	0.170

∗Beats per minute.
†Six-minute walk distance.
Data are presented as mean ± SD.