Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit

Table 1

In vitro activities of antibiotics alone (MIC, mg/L) and in combination (FIC index) with doripenem against the studied strains.

	KP-700606	KP-1	KP-2	KP-3	KP-4	KP-5	KP-6
Antibiotic
DOR	0.06	16	16	16	16	16	16
CS	1	0.5	0.25	1	1	1	1
TGC	0.12	0.25	0.125	0.125	0.06	0.25	0.125
TOB	0.5	2	1	2	1	0.5	1
LVX	0.06	1	0.03	0.06	0.125	0.5	2
RIF	512	256	256	512	256	512	512
Combination
DOR + TGC	0.75	1	0.75	0.75	0.25	1	0.75
DOR + CS	0.75	1	0.5	1	0.75	1	0.75
DOR + LVX	0.5	1	0.5	1	0.125	0.75	1
DOR + TOB	1	0.25	1	1	0.25	1	1
DOR + RIF	1	1	0.75	1	2	1	0.75

DOR: doripenem; TGC: tigecycline; CS: colistin sulphate; LVX: levofloxacin; TOB: tobramycin; RIF: rifampin. KP-700606: reference strain (Klebsiella pneumoniae ATCC 700606); KP: Klebsiella pneumoniae.