Relationship between Serum Total Cholesterol Level and Serum Biochemical Bone Turnover Markers in Healthy Pre- and Postmenopausal Women

Table 1

Clinical characteristics of the subjects based on menopausal status.

Variable	Premenopausal (𝑛=319)	Postmenopausal (𝑛=440)	𝑃 value
Age (years)	43.6±6.3	57.5±6.7	<0.001
Height (cm)	159.3±5.4	156.2±5.2	<0.001
Weight (kg)	56.0±8.0	56.8±7.3	NS
BMI (kg/m^2)	22.1±2.9	23.3±2.9	<0.001
Spine 𝑇-score	0.17±1.18	−0.93±1.27	<0.001
Femur 𝑇-score	−0.02±0.92	−0.68±0.94	<0.001
Calcium (mmol/L)	2.26±0.09	2.31±0.08	<0.001
ALP (U/L)	50.1±14.1	66.6±21.8	<0.001
Phosphorus (mmol/L)	1.16±0.16	1.24±0.17	<0.001
Total cholesterol (mmol/L)	4.75±0.78	5.15±0.81	<0.001
Triglycerides (mmol/L)	1.03±0.52	1.19±0.59	<0.001
HDL-C (mmol/L)	1.64±0.40	1.58±0.38	<0.05
hsCRP (mg/L); (median and interquartile range)	0.39 (0.26–0.73)	0.59 (0.36–1.21)	<0.001*
CTX (𝜇g/L)	309±172	546±265	<0.001
Osteocalcin (𝜇g/L)	15.40±6.00	21.69±8.58	<0.001

ALP: alkaline phosphatase; BMI: body mass index; CTX: cross-linked C-terminal telopeptide; HDL-C: high density lipoprotein cholesterol; NS: not significant; TC: total cholesterol. Values are expressed as means ± standard deviations if not otherwise specified. *Analyzed using the Mann-Whitney 𝑈-test.