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BioMed Research International
Volume 2014, Article ID 401595, 10 pages
Research Article

Adiponectin Levels Are Reduced While Markers of Systemic Inflammation and Aortic Remodelling Are Increased in Intrauterine Growth Restricted Mother-Child Couple

1Department of Woman’s and Child’s Health, Maternal Fetal Medicine Unit, University of Padua School of Medicine, Padua, Italy
2Medical and Surgical Science, University of Padua, Padua, Italy
3Clinic of Obstetrics and Gynecology, Department of Experimental Clinical and Medical Science, DISM, University of Udine, Udine, Italy
4Laboratory Medicine, University of Padua, Padua, Italy
5Maternal and Fetal Medicine Unit, Obstetrics and Gynecology, University of Padua School of Medicine, Via Giustiniani No. 3, 35128 Padua, Italy

Received 28 February 2014; Revised 13 May 2014; Accepted 4 June 2014; Published 22 June 2014

Academic Editor: Grant Drummond

Copyright © 2014 Silvia Visentin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim of the Study. To investigate the relationships between the adipocytokine levels, markers of inflammation, and vascular remodelling in pregnancies complicated by intrauterine growth restriction (IUGR). Materials and Methods. This was a retrospective study. One hundred and forty pregnant patients were enrolled. Adiponectin, leptin, tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and C reactive protein (CRP) were assessed in IUGR, small for gestational age (SGA), and appropriate for gestational age (AGA) mother-child couples at delivery. IUGR and SGA fetuses were defined as fetuses whose estimated fetal weight (EFW) was below 10th percentile for gestational age with and without umbilical artery (UA) Doppler abnormalities, respectively. Fetal aorta intima media thickness (aIMT) was evaluated by ultrasound in the same fetal groups. Data were analyzed by R (version 2.15.2). Results. There were 37 IUGR mother-child couples, 33 SGA, and 70 AGA. Leptin, TNFα, IL-6, and CRP serum levels were higher in IUGR pregnant patients ( ). Adiponectin levels were significantly reduced in IUGR fetuses compared to SGA and AGA, while leptin, TNFα, and IL-6 levels were higher in IUGR group ( ). Fetal aIMT was significantly higher in IUGR ( ) and in this group there was a negative correlation between aIMT and adiponectin/leptin ratio (A/L ratio) ( ) and between adiponectin and IL-6 levels ( ). Conclusions. In conclusion, compared to SGA and AGA, IUGR fetuses had reduced circulating levels of adiponectin and elevated measures of aIMT and several inflammatory markers. Moreover, adiponectin levels were negatively correlated with aIMT in IUGR fetuses suggesting a possible causal link between reduced adiponectin and vessel remodelling.