Differentially Expressed MicroRNAs in Maternal Plasma for the Noninvasive Prenatal Diagnosis of Down Syndrome (Trisomy 21)
Table 2
List of 36 potential biomarkers identified to be significantly differentially expressed by HT-qPCR.
Number
MicroRNA
Mean Ct of DS
Mean Ct of control
Cts
Expression in DS relative to control
value
1
Commonly identified by Cqs and NRQs
HSA-MIR-512-5P
30.97
33.66
Overrepresented
0.00861
2
HSA-MIR-483-5P
31.80
33.82
Overrepresented
0.00454
3
HSA-MIR-888-3P
30.58
34.67
Overrepresented
0.00428
4
HSA-MIR-3676-3P
33.30
31.23
Underrepresented
0.03754
5
HSA-MIR-3918
27.66
28.39
Overrepresented
0.02360
6
HSA-MIR-500A-5P
30.58
31.40
Overrepresented
0.02986
7
HSA-MIR-30C-5P
27.05
28.07
Overrepresented
0.04203
8
HSA-MIR-200C-3P
32.21
30.53
Underrepresented
0.04393
9
HSA-MIR-627
33.36
31.97
Underrepresented
0.04518
10
Identified by Cqs only
HSA-MIR-5893P
31.40
33.86
Overrepresented
0.00283
11
HSA-MIR-181A-3P
33.55
30.79
Underrepresented
0.01864
12
HSA-MIR-362-5P
31.94
34.54
Overrepresented
0.02495
13
HSA-MIR-518C-5P
31.35
35.04
Overrepresented
0.01990
14
HSA-MIR-3667-5P
30.69
33.21
Overrepresented
0.02596
15
HSA-MIR-195-3P
29.35
30.58
Overrepresented
0.03372
16
HSA-MIR-124-5P
31.72
33.32
Overrepresented
0.03635
17
HSA-MIR-498
34.42
31.45
Underrepresented
0.02934
18
HSA-MIR-18B-3P
30.71
33.30
Overrepresented
0.04078
19
HSA-MIR-1249
26.72
29.20
Overrepresented
0.04587
20
HSA-MIR-93-5P
25.76
24.76
Underrepresented
0.00944
21
HSA-MIR-20A-5P
25.04
24.27
Underrepresented
0.01837
22
HSA-MIR-4328
32.22
31.25
Underrepresented
0.02078
23
HSA-MIR-92A-3P
22.95
22.10
Underrepresented
0.02647
24
HSA-MIR-92B-3P
27.65
26.78
Underrepresented
0.02926
25
HSA-MIR-3652
30.62
31.64
Overrepresented
0.02994
26
HSA-MIR-25-3P
24.19
23.42
Underrepresented
0.03759
27
HSA-MIR-623
33.77
31.63
Underrepresented
0.03945
28
HSA-MIR-3195
23.11
24.60
Overrepresented
0.04885
29
Identified by NRQs only
HSA-MIR-423-5P
0.87
1.22
Underrepresented
0.02007
30
HSA-MIR-27B-3P
1.41
0.85
Overrepresented
0.03759
31
HSA-MIR-3135a
1.56
0.66
Overrepresented
0.04044
32
HSA-MIR-486-5P
0.83
1.66
Underrepresented
0.02598
33
HSA-MIR-3180-5P
0.71
1.17
Underrepresented
0.04036
34
HSA-MIR-629-5P
0.81
1.62
Underrepresented
0.04457
35
HSA-MIR-155-5P
0.93
1.89
Underrepresented
0.04712
36
HSA-MIR-3907
0.80
1.46
Underrepresented
0.04983
NRQs: normalized relative quantities; Cq: Ct values subtracted by background; GN: raw data, normalized to global mean data; QN: quantile normalized data; DS: Down syndrome.