CCAAT/Enhancer-Binding Protein α Is a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression

Figure 1

Putative C/EBPα binding site is located in FTO gene promoter. Human genomic sequence of FTO gene from −72 to +47 bp is shown. Asterisks indicate positions where the bases are absolutely conserved among the three species. The transcription start site (TSS) is shown as indicated in the figure. The boxed sequences represent the predicted C/EBPα (−45/−54) and Sp1 (−1/−8) binding sites based on the results of software.