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BioMed Research International
Volume 2014 (2014), Article ID 408047, 7 pages
http://dx.doi.org/10.1155/2014/408047
Review Article

Levels of Soluble E-Cadherin in Breast, Gastric, and Colorectal Cancers

1Facility of Bio-Proteomics, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy
2Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy
3Pathology Unit, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy
4Gastroenterology Unit, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Via F. Gallini 2, 33081 Aviano, Italy

Received 3 February 2014; Accepted 18 August 2014; Published 16 September 2014

Academic Editor: Alessandro Luciani

Copyright © 2014 Ombretta Repetto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Soluble E-cadherin is a 80 kDa protein fragment coming from the proteolytic cleavage of the extracellular domain of the full length epithelial cadherin, a molecule involved in cell adhesion/polarity and tissue morphogenesis. In comparison with normal epithelia, cancer cells show a decreased cadherin-mediated intercellular adhesion, and sE-cad levels normally increase in body fluids (blood and urine). This review focuses on soluble E-cadherin in sera of patients affected by three solid cancers (breast, gastric, and colorectal cancers) and how its levels correlate or not with some cancer parameters (e.g., dimension, progression, and localisation). We will describe the main proteomics approaches adopted to measure sE-cad both in vivo and in vitro and the most important findings about its behaviour in cancer dynamics.