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BioMed Research International
Volume 2014, Article ID 410457, 19 pages
Research Article

On the Coupling of Two Models of the Human Immune Response to an Antigen

Laboratory of Computational Physiology and High-Performance Computing (FISIOCOMP), Graduate Program in Computational Modeling, UFJF, Rua José Lourenço Kelmer s/n, Campus Universitário, Bairro São Pedro, 36036-900 Juiz de Fora, MG, Brazil

Received 31 January 2014; Revised 15 April 2014; Accepted 15 April 2014; Published 22 July 2014

Academic Editor: Francesco Pappalardo

Copyright © 2014 Bárbara de M. Quintela et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we propose a new model where the local tissue inflammation processes are simulated with partial differential equations (PDEs) whereas a system of ordinary differential equations (ODEs) is used as a model for the systemic response. The simulation of distinct scenarios allows the analysis of the dynamics of various immune cells in the presence of an antigen. Preliminary results of this approach with a sensitivity analysis of the coupled model are shown but further validation is still required.