Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 412570, 10 pages
http://dx.doi.org/10.1155/2014/412570
Research Article

Different Effects of Implanting Sensory Nerve or Blood Vessel on the Vascularization, Neurotization, and Osteogenesis of Tissue-Engineered Bone In Vivo

1Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
2Department of Orthopaedics, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, China
3Department of Orthopaedics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China

Received 29 March 2014; Accepted 2 June 2014; Published 30 June 2014

Academic Editor: Zhi-Yong Zhang

Copyright © 2014 Jun-jun Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. K. Sen and T. Miclau, “Autologous iliac crest bone graft: should it still be the gold standard for treating nonunions?” Injury, vol. 38, supplement 1, pp. S75–S80, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. W. Waked and J. Grauer, “Silicates and bone fusion,” Orthopedics, vol. 31, no. 6, pp. 591–597, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Mahendra and A. Maclean, “Available biological treatments for complex non-unions,” Injury, vol. 38, supplement 4, pp. S7–S12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Chugh, D. S. Marks, D. C. Mangham, and A. G. Thompson, “Autologous bone grafting in staged scoliosis surgery: the patient as bone bank,” Spine, vol. 23, no. 16, pp. 1793–1795, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. E. L. Burger and V. Patel, “Calcium phosphates as bone graft extenders,” Orthopedics, vol. 30, no. 11, pp. 939–942, 2007. View at Google Scholar · View at Scopus
  6. J. M. Kanczler and R. O. Oreffo, “Osteogenesis and angiogenesis: the potential for engineering bone,” European Cells & Materials, vol. 15, pp. 100–114, 2008. View at Google Scholar · View at Scopus
  7. C. M. Serre, D. Farlay, P. D. Delmas, and C. Chenu, “Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers,” Bone, vol. 25, no. 6, pp. 623–629, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Kawamura, H. Yajima, H. Ohgushi et al., “Experimental study of vascularized tissue-engineered bone grafts,” Plastic and Reconstructive Surgery, vol. 117, no. 5, pp. 1471–1479, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. U. Kneser, E. Polykandriotis, J. Ohnolz et al., “Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop,” Tissue Engineering, vol. 12, no. 7, pp. 1721–1731, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Hokugo, Y. Kubo, Y. Takahashi et al., “Prefabrication of vascularized bone graft using guided bone regeneration,” Tissue Engineering, vol. 10, no. 7-8, pp. 978–986, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Arkudas, J. P. Beier, K. Heidner et al., “Axial prevascularization of porous matrices using an arteriovenous loop promotes survival and differentiation of transplanted autologous osteoblasts,” Tissue Engineering, vol. 13, no. 7, pp. 1549–1560, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Cui, G. Pei, and S. Jiang, “A study of the different effect on the expression of calcitonin gene related peptide and neuropeptide Y in tissue engineered bone with vascular bundle graft in vivo and that with sensory nerve tract graft in vivo,” Zhonghua Wai Ke Za Zhi, vol. 46, no. 16, pp. 1249–1252, 2008. View at Google Scholar · View at Scopus
  13. S. Chen, J. Qin, L. Wang et al., “Different effects of implanting vascular bundles and sensory nerve tracts on the expression of neuropeptide receptors in tissue-engineered bone in vivo,” Biomedical Materials, vol. 5, no. 5, Article ID 55002, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Jiang, Y. Liu, Q. Wang et al., “Experimental study on construction of neurotization tissue engineered bone for repairing large bone defects in rabbit,” Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, vol. 24, no. 5, pp. 599–605, 2010. View at Google Scholar · View at Scopus
  15. C. Y. Yang, D. J. Simmons, and R. Lozano, “The healing of grafts combining freeze-dried and demineralized allogeneic bone in rabbits,” Clinical Orthopaedics and Related Research, no. 298, pp. 286–295, 1994. View at Google Scholar · View at Scopus
  16. E. Polykandriotis, A. Arkudas, R. E. Horch, M. Stürzl, and U. Kneser, “Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science,” Journal of Cellular and Molecular Medicine, vol. 11, no. 1, pp. 6–20, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. U. Kneser, D. J. Schaefer, E. Polykandriotis, and R. E. Horch, “Tissue engineering of bone: the reconstructive surgeon's point of view,” Journal of Cellular and Molecular Medicine, vol. 10, no. 1, pp. 7–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. E. L. Hohmann, R. P. Elde, J. A. Rysavy, S. Einzig, and R. L. Gebhard, “Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers,” Science, vol. 232, no. 4752, pp. 868–871, 1986. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Imai, Y. Tokunaga, T. Maeda, M. Kikkawa, and S. Hukuda, “Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase- immunoreactive innervation of rat bone marrows: an immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms,” Journal of Orthopaedic Research, vol. 15, no. 1, pp. 133–140, 1997. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Sisask, A. Bjurholm, M. Ahmed, and A. Kreicbergs, “The development of autonomic innervation in bone and joints of the rat,” Journal of the Autonomic Nervous System, vol. 59, no. 1-2, pp. 27–33, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Sakai, T. Nakamura, H. Tsurukami et al., “Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice,” Bone, vol. 18, no. 5, pp. 479–486, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Kjaer, “Correlated appearance of ossification and nerve tissue in human fetal jaws,” Journal of Craniofacial Genetics and Developmental Biology, vol. 10, no. 3, pp. 329–336, 1990. View at Google Scholar · View at Scopus
  23. I. Kjaer, “Neuro-osteology,” Critical Reviews in Oral Biology & Medicine, vol. 9, no. 2, pp. 224–244, 1998. View at Google Scholar
  24. B. Lanske, M. Amling, L. Neff, J. Guiducci, R. Baron, and H. M. Kronenberg, “Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development,” The Journal of Clinical Investigation, vol. 104, no. 4, pp. 399–407, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Cornish, K. E. Gallon, C. Q. Lin et al., “Comparison of the effects of calcitonin gene-related peptide and amylin on osteoblasts,” Journal of Bone and Mineral Research, vol. 14, no. 8, pp. 1302–1309, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. S. M. D'Souza, I. MacIntyre, S. I. Girgis, and G. R. Mundy, “Human synthetic calcitonin gene-related peptide inhibits bone resorption in vitro,” Endocrinology, vol. 119, no. 1, pp. 58–61, 1986. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Drissi, M. Lieberherr, M. Hott, P. J. Marie, and F. Lasmoles, “Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4),” Cytokine, vol. 11, no. 3, pp. 200–207, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Villa, C. Dal Fiume, A. Maestroni, A. Rubinacci, F. Ravasi, and F. Guidobono, “Human osteoblast-like cell proliferation induced by calcitonin-related peptides involves PKC activity,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 284, no. 3, pp. E627–E633, 2003. View at Google Scholar · View at Scopus
  29. A. Vignery and T. L. Mccarthy, “The neuropeptide calcitonin gene-related peptide stimulates insulin-like growth factor I production by primary fetal rat osteoblasts,” Bone, vol. 18, no. 4, pp. 331–335, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. G. D. Roodman, “Mechanisms of bone metastasis,” The New England Journal of Medicine, vol. 350, no. 16, pp. 1655–1664, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. S. R. Haug and K. J. Heyeraas, “Modulation of dental inflammation by the sympathetic nervous system,” Journal of Dental Research, vol. 85, no. 6, pp. 488–495, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. N. J. Lee and H. Herzog, “NPY regulation of bone remodelling,” Neuropeptides, vol. 43, no. 6, pp. 457–463, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. W. Deng, T. J. Bivalacqua, N. N. Chattergoon, J. R. Jeter Jr., and P. J. Kadowitz, “Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector,” Stem Cells, vol. 22, no. 7, pp. 1279–1291, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. J. N. de Hoon, P. Pickkers, P. Smits, H. A. Struijker-Boudier, and L. M. van Bortel, “Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans,” Clinical Pharmacology & Therapeutics, vol. 73, no. 4, pp. 312–321, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Hirata, Y. Takagi, S. Takata, Y. Fukuda, H. Yoshimi, and T. Fujita, “Calcitonin gene-related peptide receptor in cultured vascular smooth muscle and endothelial cells,” Biochemical and Biophysical Research Communications, vol. 151, no. 3, pp. 1113–1121, 1988. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Qing and I. M. Keith, “Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats,” American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 285, no. 1, pp. L86–L96, 2003. View at Google Scholar · View at Scopus
  37. J. Clarke, N. Benjamin, S. Larkin, D. Webb, A. Maseri, and G. Davies, “Interaction of neuropeptide Y and the sympathetic nervous system in vascular control in man,” Circulation, vol. 83, no. 3, pp. 774–777, 1991. View at Publisher · View at Google Scholar · View at Scopus
  38. B. E. Lindblad, L. B. Nielsen, S. M. Jespersen, A. Bjurholm, C. Bunger, and E. S. Hansen, “Vasoconstrictive action of neuropeptide Y in bone: the porcine tibia perfused in vivo,” Acta Orthopaedica Scandinavica, vol. 65, no. 6, pp. 629–634, 1994. View at Google Scholar · View at Scopus