Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
Histological evaluation of gastric mucosa in the ethanol-induced ulcerated rats. (a) Rats pretreated with 0.5% CMC only (normal control). Intact gastric mucosa layer are seen; (b) rats pretreated with 0.5% CMC (5 mL/kg, ulcer control). There is severe destruction to surface epithelium and necrotic lesions are present; (c) rats pretreated with omeprazole (20 mg/kg, positive control). Less disruption to gastric mucosa layer with mild leucocyte infiltration and edema; (d) rats pretreated with low dose of C. xanthorrhiza leaf extract (250 mg/kg). No disturbance to gastric mucosa layer; (e) rats pretreated with high dose of C. xanthorrhiza leaf extract (500 mg/kg). No disturbance to gastric mucosa layer. The black arrow indicates leucocytes infiltration and edema in submucosal layer; yellow arrow indicates disruption to the surface epithelium and deep mucosa (Haematoxylin and Eosin stain, 40x).